Principal Research Scientist, Immunology Discovery
At Abbvie Immunology, we focus on investigating novel solutions to help improve patient care across a variety of autoimmune and chronic inflammatory diseases with unmet needs. We focus our target discovery efforts on pathways that have direct correlates with disease activity and patient symptoms with a strong emphasis on the use of genomics and other omics data to inform target selection. We have an exciting opportunity for a Principal Scientist at our Foundational Immunology Early Discovery unit based in Cambridge, MA.
We are seeking a highly motivated and talented individual with a PhD in immunology with in-depth scientific knowledge of T cell biology in inflammatory bowel diseases and other autoimmune disorders. The position offers a unique opportunity for a talented scientist to work in a dynamic, innovative, and multi-disciplinary environment to develop their career at the interface of basic research, target discovery and early drug discovery.
Key responsibilities Include:
- Identification, prioritization and validation of potential novel targets for the treatment of inflammatory conditions.
- Thoroughly review literature data, with the ability to capture the essence of target biology and conceptualize target therapeutic hypotheses and develop strategic plans for target validation.
- Design, develop, evaluate and implement well-controlled in vitro and in vivo studies to interrogate target and drug biology, and generate proof of concept data supporting target Go/No Go decisions.
- Planning and coordination of experiments with internal and external team members and facility operations.
- Analysis and presentation of data, providing scientific interpretations and recommendations in lab meetings and project team meetings.
- Maintaining accurate and well-organized records including laboratory notebooks.
- Supporting development of protocols, study reports and data presentations by junior scientists.
- People skills to supervise and coach junior scientists in the lab.
- BS, MS or PhD in immunology with 16+ (BS), 14+ (MS) 8+ (PhD) years of experience including at least 5 years of intensive experience in drug discovery with a strong background in molecular and cellular immunology, specifically in human auto-immune diseases, with an emphasis on T cell biology.
- Demonstrated ability of leading early drug discovery program from target nomination and therapeutic concept development all the way to target validation and drug development candidate identification, preferably with experience in small molecule and biologics drug discovery.
- Proficient in laboratory skills such as animal models, including tissue handling for molecular and cellular phenotyping, multicolor flow cytometry and cell sorting, and knowledge in gene and protein cellular and tissue expression validation.
- Experience in in vitro immune assays like - Dendritic cell differentiation assay, T cell proliferation assay, CTL assay, T cell polarization assays. Knowledge of in vivo PD and mouse IBD model systems would be a plus.
- Experience in generating knockout, knockdown or enzymatically inactive target protein cell systems using approaches such as siRNA, shRNA and CRISPR for testing target validation hypotheses is desirable.
- Basic immunological and molecular biology assay skills: Tissue culture, Transfection, ELISA, Western blot, immunoprecipitation, ELISPOT, intracellular cytokine analysis and Luciferase assays.
- General knowledge in OMICS datasets generated by methods such as RNAseq and CyTOF, etc. and bioinformatics analysis such as IPA and t-SNE.
- Excellent communication and organizational skills.
- Must be a quick-learner and a team-player.
- A proven track record of publications, patents and progressing pipeline projects.
Key AbbVie Competencies:
- Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.
- Learns fast, grasps the “essence” and can change course quickly where indicated.
- Raises the bar and is never satisfied with the status quo.
- Creates a learning environment, open to suggestions and experimentation for improvement.
- Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Equal Opportunity Employer Minorities/Women/Veterans/Disabled