Principal Scientist, Biology
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer. More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in cell-signaling, immuno-oncology, and cancer stem cells with their knowledge of covalent-inhibitor, bispecific antibodies, and antibody-drug conjugates (ADCs) technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer and restore the Magic of Normal for our patients. Pharmacyclics is seeking a highly motivated Principal Scientist in research biology with a proven track record of accomplishments to direct the disease biology research and drug discovery projects. This position is responsible for providing strong scientific, drug discovery and research team leadership to drive novel target discovery, small molecule drug development, and mechanism-of-action research in the field of hematological malignancies and immune oncology. Expertise in lymphoma/leukemia biology/pathology, immunology and drug discovery is required. Key Accountabilities/Core Job Responsibilities:
Conceive, communicate and execute novel multi-disciplinary research strategies that encompass target validation, small molecule drug discovery as well as early development agents.
Design and implement hypothesis-driven proposals to enable structure-activity relationships or mechanisms of action of drugs in hematological malignancies and immune-oncology.
Propose and validate novel therapeutic targets by combining deep understanding of mechanistic biology in hematological malignancies and immune oncology with human genetics and pathology.
Design and execute in vitro or ex vivo experiments to determine potency and selectivity of drug candidates using cell lines and primary human cell sources. Lead the development, optimization, and validation of new assays. Utilize technical expertise and available information to troubleshoot and resolve key project hurdles when encountered.
Perform pharmacology experiments to analyze pharmacodynamic biomarkers and to understand the disease mechanism, drug function and patient selection.
Effectively direct a group of discovery scientists in generating innovative technical and new target strategies that lead to the discovery of novel oncology therapeutic agents.
Interact with cross-functional teams (medicinal chemistry, DMPK, pharmacology, safety/toxicology etc.) to establish productive collaborations within and outside of Pharmacyclics. Develop compelling scientific presentations and reports for internal review meetings and external scientific conferences/journals.
Represent the department on a cross-functional team driving early projects and ensuring execution of a robust screening funnel.
Manage preclinical and early clinical research to support the development of small molecule drug candidates in hematological malignancies and immune oncology.
Direct and carry out multiple scientific endeavors simultaneously, including both basic and translational research to advance our clinical and preclinical compounds.
Actively participate in internal and external scientific meetings by presenting and critically evaluating the science and contributing to projects.
Prioritize tasks and contribute to a highly motivated and productive research department with a sense of urgency and desire to meet project timelines.
Play an active role on the department leadership team, setting and implementing strategy as well as providing strong leadership and mentoring project teams and personnel.
- PhD in molecular/cell biology, cancer biology, immunology, genetics or pharmacology with >10 years industry experience in small molecule oncology drug discovery and development
- Broad training in cancer biology, ideally in hematological malignancies, and a deep understanding of mechanistic cancer biology, translational science and current trend in oncology therapeutics. Proven scientific leadership in mechanism of action and translational studies. Knowledge and experience in cancer genetics, genomics and bioinformatics are strongly preferred.
- Deep expertise and extensive experience in small molecule drug discovery, from target discovery/validation to candidate nomination and with the ability to integrate in vitro and in vivo pharmacology, is necessary.
- Biology lead for small molecule drug discovery projects leading to IND filing for oncology therapeutics.
- Strong hands-on technical skills in lymphoma/leukemia research and/or immune oncology research. Working experience with in vivo oncology disease models.
- Demonstrated record of creativity and scientific achievements with strong publication and/or patent record.
- Experience in communicating technical information to a broad scientific audience through presentations, and written reports is essential.
- Proven track record in recruiting, building, managing and developing productive and effective research teams with PhD and associate scientists.
- Experience in successful collaborative teamwork in a matrix environment.
- Effective written and verbal communication skills.