Sr. Associate/Principal Associate-Process Development Upstream

Location
San Diego, CA, United States
Posted
Jun 15, 2018
Ref
1-149
Hotbed
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time
Company Description:

PaxVax is a privately held global specialty vaccines company focused on the travel and endemic disease markets with a mission to develop and commercialize innovative vaccines against infectious diseases in a socially responsible manner. The company headquarters are located in Redwood City, California and R&D and GMP manufacturing sites are in San Diego, California and Bern, Switzerland. The Company has a commercial vaccine (Vivotif® oral typhoid vaccine) that is licensed in over 30 countries and an oral vaccine for cholera that is currently completing Phase 3 clinical development. Our clinical stage portfolio also includes vaccine candidates for pandemic influenza (H5N1), anthrax, and HIV, and we are pursuing preclinical programs in dengue, malaria, and herpes. PaxVax is committed to continued growth in its product portfolio, and in continuing collaboration with academic, government, and industrial partners. More information is available at www.PaxVax.com.

Summary Description of Role:

This is an incredible opportunity to join a small but growing clinical stage pharmaceutical company with a bright future. The main responsibilities will include the design, execution, and documentation of experiments to develop/optimize upstream (bioreactor, transfection, microfiltration, filtration) for clinical supply production and to scale up these processes to enable transfer of robust processes to the commercial stage. The successful candidate will be able to work in a fast-paced team oriented environment and be able to learn new skills quickly. This position will report to the Sr. Scientist/Manger, process development.

Responsibilities:

Deep understanding of bio-chemical and physical properties of therapeutic biomacromolecules including but not limited to proteins and viral-like particles

Optimize mammalian cell culture and viral amplification in 10L to 200L bioreactor

Understanding of the drug product manufacturing process and scale-up considerations

Optimize transient transfection process to improve product yield

Author process development summary and tech reports

Author manufacturing SOPs and batch records

Qualification Requirements:

Bachelors of Science/engineering in Biology, chemistry, chemical engineering, or related discipline

Minimum of 6 years' relevant industry experience, or MS degree plus the knowledge and skills acquired through 3 years' relevant industry experience

Team player and collaborator, ability to listen and communicate clear and timely manner

Cell culture experience and Good aseptic techniques required

Bioreactor experience is preferred/required

Diafiltration/Ultrafiltration experience is preferred

Familiar with design of experiment

Basic understanding of Universal Precautions and Basic Lab safety

Skilled with use of word processing, spreadsheets, graphical and presentation software applications

Basic knowledge of laboratory procedures, established techniques, instruments and equipment, GLP or GMP experience is preferred

Capable of searching scientific literature to gain information about specific topics

Demonstrate an ability to think and act independently; accept supervision, work quickly and accurately in a fast-paced environment, critically analyze data and proactively solve problems

Travel:

None