Senior Research Associate, Cell Biology

Location
South San Francisco, California
Posted
Jun 11, 2018
Required Education
Bachelors Degree
Position Type
Full time

The qualified candidate will join a team focused on developing and executing biochemical and cell-based assays for small molecule lead identification/optimization and deciphering their mechanism of action. In this position you will support drug discovery efforts by providing cell biology expertise and services.

 Responsibilities:

  • Develop and execute biological assays (biochemical and cell-based) in 96-well or 384-well format
  • Analyze molecules’ mechanism of action utilizing flow cytometry, immunofluorescence, western, qPCR, apoptosis assays
  • Culture a variety of cancer cell lines and primary cells
  • Prepare assay reagents, compound serial dilutions
  • Perform data analysis, reporting and integration with GraphPad Prism, Microsoft Office and other software packages
  • Contribute to or lead lab management activities

Qualifications and Experience:

  • BS or MS in related scientific discipline
  • 3-6 years of industry experience in cell biology and compound profiling
  • Previous experience in cell culture, compound handling are must have
  • Proficiency in enzymatic assays and cell-based assays
  • Experience with protein analysis: MSD, AlphaLISA/AlphaScreen, western, flow cytometry, immunofluorescence, ELISA
  • Experience with DNA and RNA isolation, qPCR and other RNA analysis techniques
  • Experience with generation of stable cell lines, conditional gene knockdown/expression
  • Excellent computer skills combined with data analysis
  • Must be detail oriented, well organized, and have strong communication skills
  • Capable of fully understanding scope of projects and able to troubleshoot and identify solutions to arising issues
  • Excellent teamwork skills and the ability to work under the supervision of a senior member of the biology group, in a fast-paced, multi-disciplinary environment
  • Excellent work ethic, self-motivated, driven, dependable, hardworking

About ORIC Pharmaceuticals:
ORIC Pharmaceuticals is a privately held oncology company focused on making cancer treatments more effective by addressing mechanisms of resistance. ORIC was founded by Drs. Charles Sawyers MD and Scott Lowe PhD, who have strong records of discovering innovative treatments and targets in cancer. The company has assembled strong leadership and scientific teams and a board with extensive experience in drug development and financing. ORIC is funded by leading biotechnology investors, including The Column GroupTopspin PartnersOrbiMed AdvisorsEcoR1 Capital, Fidelity Management & Research Company, Trinitas Capital, Foresite Capital, Taiho Ventures, Memorial Sloan Kettering, Kravis Investment Partners and NS Investment. ORIC is headquartered in South San Francisco, California.