Bristol-Myers Squibb is actively conducting translational medicine research to further our understanding of cancer biology and to identify which patient populations may be more likely to derive benefit from Immuno-Oncology (I-O). Bristol-Myers Squibb has long believed the future of cancer research is dependent on investments in science and partnerships. Collaboration is integrated into our organizational framework across translational medicine and R&D.
The Clinical Biomarker Scientist is responsible for developing and executing on translational strategies for the Oncology and Cardiovascular, Immunoscience, Fibrosis and Genetically Defined Diseases (GDD) pipeline. This scientist works on various projects across all stages of drug development and will act as a key interface with the Translational Medicine group.
The successful candidate will be responsible for integrating translational research and clinical development, developing a biomarker strategy in alignment with clinical development objectives, leading efforts for data generation, interpretation and communication to the development teams. The candidate will also be responsible for understanding the external research environment, partnering with discovery biology and other functions both internally and with external partners to coordinate the execution of deliverables.
- Independently engages with development teams and technical/scientific experts to define, revise and progress biomarker plans.
- Effectively engages with teams and governance bodies and utilizes advisory bodies to define, revise and progress biomarker plans
- Delivers high quality biomarker strategies for target engagement, pharmacodynamic endpoints and patient selection (where appropriate).
- Continually analyzes progress, engages in critical thinking, and asserts strong problem-solving toward delivering key data and interpretation essential for decision making on assigned enterprise level efforts
- Ensures the output of the biomarker plans meets established program standards (within budget, on schedule, compliant, etc.), while also looking for opportunities to streamline progress without compromising quality.
- Proactively provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles.
- Effectively interfaces with the Translational Medicine group to obtain appropriate resources to deliver on biomarker goals.
- Collaborates and strategizes across the entire Oncology organization to improve efficiency and accelerate the product pipeline forward.
- Communicates key biomarker program information, risks, and milestones, and manages information flow across key stakeholders including therapeutic area leadership, functional leads and team members.
- As appropriate, provides biomarker expertise to progress validated biomarkers into development of pharmacodiagnostic tools.
This position will report to the Group Head Early Biomarkers and is based in Lawrenceville, New Jersey.
- MD or PhD, or equivalent advanced biology degree
- Experienced scientist with 9+ years' experience in the drug development process.
- Deep understanding of the role of translational research/medicine and clinical biomarkers in drug development
- Comfortable working in a fast-paced environment where speed is paramount
- Willing to work as a topic expert, outside of a traditional functional environment, in a team unified around serving the assets
- Ability to recognize, articulate, and accept calculated risks to make informed decisions
- Willingness and ability to effectively cooperate and partner with external providers and others within BMS
- Demonstrated experience in the appropriate application of various scientific technologies into translational research strategies
- Working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, etc.
- Demonstrated scientific acumen and mechanistic understanding of disease biology