Scientist I/II-Metabolic Engineering
At Synthetic Genomics, Inc., we are dedicated to developing and commercializing genomic-driven solutions to address global challenges. We are currently seeking a Scientist I/II to join our fast-growing, dynamic and collaborative team in La Jolla, CA.
The Scientist I/II will join the metabolic engineering & synthetic biology team within the Heterotrophic Cell Systems Unit, which focuses on the research and development of novel host production systems for biotechnological and biopharmaceutical applications. The successful candidate will apply knowledge and learnings of metabolic engineering with the synthetic biology tools developed at Synthetic Genomics to achieve key strain performance deliverables leading to commercially viable strains with an emphasis on the production of therapeutics. The successful candidate will have extensive experience in metabolic engineering, microbial genetics, molecular biology, protein biochemistry, significant exposure to transcriptomics, proteomics and bioinformatics data.
- The Scientist will work in a matrix environment and contribute significant intellectual input into the design of experiments, employing synthetic biology techniques to engineer strains towards program objectives.
- Carefully execute laboratory experiments to generate engineered strains.
- Expertise in recombinant protein expression using microbial hosts.
- Thorough understanding of Eukaryotic protein secretion.
- Contribute to overall success of science program(s), on-going projects, critical patents, grants or scientific publications.
- Must possess excellent communication and interpersonal skills to facilitate interactions with a highly interdisciplinary team.
- Summarize and present data at regular team meetings.
- Consistently demonstrate initiative in implementing projects and/or necessary work.
- Knowledge of microbial physiology, fermentation, and protein biochemistry is preferred
- Requires a Ph.D. in Genetics, Microbiology, Biochemistry, Chemical Engineering or a related field and 0-4 years of relevant postdoctoral or industrial experience.
- Expertise improving recombinant protein expression using microbial hosts.
- Proficiency with Eukaryotic secretion pathways
- Fluency and practical knowledge of modern synthetic biology techniques and state of the art molecular biology software.
- Expertise engineering N-glycosylation pathways is preferred.
- Publications demonstrating experience working with non-traditional and/or industrial microorganisms is not essential but desirable.
- Demonstrated know-how using bioinformatics to improve strain engineering outcomes is preferred.