Senior Scientist/Associate Director - Protein Engineering

San Diego, CA
Jun 06, 2018
Required Education
Masters Degree/MBA
Position Type
Full time

Job Description

Metacrine is a dynamic, driven small company headquartered in San Diego, CA. The company is focused on advancing novel molecules for treatment of metabolic diseases.  

We are looking for a highly motivated scientist with experience in protein engineering, expression, purification and analytical characterization.  The candidate will lead protein engineering efforts on our type 2 diabetes program focused on a novel insulin sensitizer.  Ideal candidate will lead from the bench and have hands on experience with cloning, bacterial expression and purification.  S/he will work closely with the biology group to advancement the project from lead target identification to clinical candidate nomination. 

Required Stills

  • Direct protein engineering for bacterial expression for small scale in vitro screening and scale-up production with low endotoxin for in vivo testing
  • Demonstrated expertise in state of the art technologies employed for recombinant DNA manipulation including but not limited to cloning, site-directed mutagenesis, codon optimization, and/or gene synthesis
  • Broad knowledge of protein analytical technology including chromatographic methods such as HPLC (SEC, IEX, RP, and IEF), mass spectroscopy, electrophoresis (SDS-PAGE, Western Blots), differential scanning fluorimetry, and LAL endotoxin analysis.
  • Experience with automated protein purification techniques using GE’s AKTA systems
  • Experience with protein stability and formulation a plus
  • Present at team meetings to provide timely input and scientific guidance to progress the programs forward
  • Maintain inventory and records of expression constructs and proteins
  • Experience with molecular modeling and SAR analysis a plus

Required Experience

  • Masters or PhD in Biochemistry, Molecular Biology, Chemical Engineering or related field.
  • 5-10 years recombinant protein expression experience in pharmaceutical or biotechnology industry
  • Previous experience in managing direct reports
  • Strong written and verbal skills
  • Ability to work both collaboratively and independently in a fast-passed environment

Please include cover letter highlighting relevant experience and expertise.