Vertex Pharmaceuticals

Associate Director DMPK

Boston, MA
Jun 06, 2018
Required Education
Position Type
Full time

Vertex is seeking a talented individual to join our Drug Metabolism and Pharmacokinetics group in Boston, MA. We are seeking a highly skilled and passionate DMPK Senior Manager or Associate Director to support our small molecule drug discovery and development teams. The qualified candidate will work closely with our established in vitro ADME team performing CYP inhibition, CYP induction, drug transporter and other cell based assays. The selected individual will assist DMPK team members in Boston and across sites to analyze and interpret data which will be presented in a multidisciplinary team environment. In addition, the selected individual will also have opportunities to represent DMPK on disease area project teams. 

Key Responsibilities: 

Assessment/prediction of potential drug-drug interactions mediated by CYP inhibition, induction and drug transporters.  Evaluation and implementation of state-of-art in vitro technologies to assess drug-drug interaction potential of compounds.  Scientific mentorship and supervision of laboratory personnel is necessary.  Proficiency in PBPK modeling using software such as Gastroplus and SimCYP is a plus.

Minimum Qualifications

  • PhD in Biological Sciences/Pharmaceutical Sciences plus 7+ years of direct experience working in the Pharmaceutical Industry.
  • Direct work experience in the field of CYP induction, inhibition and drug transporters, with strong cell culture expertise.
  • Must be highly motivated, organized with excellent communication skills (both oral and written), detail oriented, and a good team player.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. 

Founded in 1989 in Cambridge, Mass., Vertex today has research and development sites and offices around the world. For several consecutive years, Science magazine has named Vertex one of its Top Employers in the life sciences. For additional information and the latest updates from the Company, please visit 

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at