Scientist II, Molecular and Cellular Pharmacology

Employer
Celgene
Location
San Diego, CA
Posted
Jun 05, 2018
Ref
1801849
Required Education
Bachelors Degree
Position Type
Full time

Other Locations:US- CA- San Diego


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

The Molecular and Cellular Pharmacology Group in the Protein Homeostasis Thematic Center of Excellence (PH TCoE) focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation.  We are seeking a motivated Scientist with broad experience and deep understanding of the small-molecule drug discovery processes.  The successful candidate will work collaboratively in a multi-disciplinary environment to implement robust cellular assays to support discovery of small molecules as clinical development candidates. The desired candidate should have a good understanding of how to set up and monitor the performance of key SAR assays supporting chemistry efforts, strong analytical capability, excellent skills in data management and automation.  Responsibilities include utilizing cellular models to develop and execute relevant SAR assays, designing templates for routine data analysis, performing cross experiment analysis, and assisting other scientists to trouble shoot for assay-related issues. The candidate will work within discovery project teams and with scientists across different functional areas and is expected to actively contribute to project based decision making.

Protein Homeostasis at Celgene

The PH TCoE at Celgene is one of the fundamental research and early development engines delivering therapeutics to patients.  As a thematic center, the PH TCoE is agnostic to therapeutic modality or disease area. The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability. This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company's most advanced drugs. Not being bound by disease area or therapeutic modality creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.

Responsibilities will include but are not limited to the following:

  • Serve as the “go-to” person for SAR assay implementation, data management, and automation.

  • Develop and implement relevant cell based assays for identification, optimization, and characterization of novel chemical matter

  • Design and conduct essential experiments in cell biology, molecular biology, and assay development.

  • Analyze and present data in an organized and timely manner

  • Work within and support biology needs for drug discovery teams

Requirements:

  • Bachelor's degree in a scientific discipline with at least 12 years work experience, Master's degree with at least 10 years work experience or Ph.D. in a scientific discipline with at least 4 years of work experience.

  • Extensive knowledge in small molecule drug discovery process in an industrial setting. 

  • Hands on experience with the discovery of new small molecule entities and lead identification / optimization. 

  • Understand key aspects of SAR support using biological assays.

  • Deep understanding of curve fitting models and analysis across various assay types and drug mechanisms. 

  • Capable of analyzing routine SAR data as well as large complex biological data in a well-organized and efficient manner. 

  • Familiar with Excel, XLFit, Prism, Abase, Sargen/Sarview, Dotmatics, electronic notebook, CalcuSyn, IncuCyte Zoom/S3, or other databases for compound-related data analysis. 

  • Capable of template and protocol design.

  • Experience in mammalian cell culture including primary cell culture is a must. 

  • Previous hands-on experience in various cell-based assays including, but not limited to, proliferation, apoptosis, cell cycle analysis, ELISA, Western blotting, and quantitative PCR is required.

  • Familiar with various biology laboratory equipment with an emphasis on automation and capable of trouble shooting for SAR assay support.

  • Excellent communication, presentation, collaboration, and organizational skills. Capability to stay focused and deliver high quality data in a timely and well organized manner.

  • Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude.
     

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BIO-US

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.