Research Associate - In Vitro (DMPK)

94080, South San Francisco
Jun 01, 2018
Required Education
Bachelors Degree
Position Type
Full time


Position Summary:

The Drug Metabolism and Pharmacokinetics (DMPK) Department at Global Blood Therapeutics is looking for a qualified research associate with experience performing in vitro DMPK assays. He/she will be responsible for performing for a variety of in vitro ADME assays such as microsomal and hepatocyte stability, CYP inhibition, reaction phenotyping, solubility, protein binding etc. The candidate should be familiar with LC-MS operation as well as sample extraction techniques such as LLC and SPE.  The ideal candidate should be able perform routine LC-MS/LC-UV maintenance and troubleshooting.  

Essential Duties and Responsibilities:

  • Perform in vitro DMPK screening assays for small molecules such as stability (microsomes, hepatocytes, and plasma), CYP inhibition, reaction phenotyping, solubility, protein binding etc.
  • Analyze and report data in a timely manner
  • Maintain laboratory notebook
  • Perform routine LC-MS/LC-UV maintenance 

Minimum Requirements:

  • BA/BS/MS in relevant field with 1+ years’ experience in drug metabolism and pharmacokinetics within a pharmaceutical company preferred or academic equivalent.
  • A minimum of 1 year of experience with LC-MS operation (experience with ABSciex a plus).
  • A solid knowledge and hands-on experience with in vitro DMPK assays is preferred.
  • Good communication skills and ability to work in a team-based environment is essential.  

Fit with GBT culture:

  • Ability to build strong relationships with co-workers of various backgrounds and expertise
  • Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
  • Values-based leadership consistent with GBT's Core Values
  • Excitement about the vision and mission of GBT
  • Flexibility
  • Integrity

NOTE:  This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.

Global Blood Therapeutics is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or any other characteristic protected by law.