Bioprocess Development Scientist - Pivotal Drug Substance
Amgen focuses on areas of high unmet medical need, striving for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies and has developed a diverse pipeline of medicines with breakaway potential.
The Pivotal Drug Substance Technologies organization at Amgen develops, characterizes and supports the commercialization of the drug substance manufacturing processes for all late-stage programs across the Amgen portfolio.
Located at our Thousand Oaks California site, the bioprocess scientist will be responsible for the development, characterization, scale-up and support of processes from cell to drug substance. The bioprocess development group enables advancement of programs from Ph II/III clinical trials to the marketing application and commercial launch. The bioprocess scientist will be central to an integrated group where cell-culture and purification scientists work in combined teams to advance Amgen's dynamic pipeline. With Amgen's biology first approach, the position provides a unique opportunity to work on multiple modalities, from antibodies and oncolytic viruses to bi-specifics and siRNAs. The candidate will apply established platform approaches to rapidly solve cell-culture challenges and design robust processes with efficient experimentation. Additionally, the candidate will drive new approaches and utilize out-of-the-box thinking to contribute to technology development. Finally, the candidate will demonstrate the desire to expand and develop skills in harvest and purification, thereby contributing to the integrated bioprocess development approach.
Doctorate degree or PhD expected by August 2018
Master's degree and 4 years scientific experience
Bachelor's degree and 6 years scientific experience
Doctorate (PhD) in Chemical Engineering, Biochemical Engineering, or other relevant scientific field
Proven track record problem solving and trouble-shooting cell-culture and harvest processes, in a process development environment
Strong understanding and extensive hands-on experience in fed-batch, and perfusion bioreactor process design and troubleshooting
Experience in harvest operations, including centrifugation, depth filtration, and tangential flow filtration (TFF)
Demonstrated ability to independently identify, develop and implement scientific solutions to practical problems
Motivated self-starter with excellent interpersonal and organizational skills
Leadership experience of progressively increased scope and a demonstrated ability to inspire and lead a group of scientists to deliver on complex and challenging objectives in defined timelines
Demonstrated eminence in the scientific community through a sustained record of peer reviewed publications
Excellent verbal communication and scientific writing skills
Demonstrated success working with diverse team members in a dynamic, cross-functional environment
Familiarity with software-based design of experiments, statistical analysis of data, and data visualization
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.