Assay Development Scientist, Protein Biochemistry

Location
Tarrytown, New York, US
Posted
May 19, 2018
Ref
10833BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:
The Scientist position in Protein Biochemistry will be responsible for the development of Host Cell Protein (HCP) detection and quantitation assays. Host Cell Proteins (HCP) and process related contaminants are biological impurities that may remain in recombinant drug products even after extensive purification. These impurities pose potential safety risks to patients resulting from their known immunogenicity effects. The proper identification and quantitation of these impurities is critical in producing a safe therapeutic.

Responsibilities:
The individual will be working on developing complex Enzyme-linked immunosorbent assays (ELISA) and CE-western methods to support the detection and quantitation of total HCP in in-process and DS samples. The individual will work with CROs to generate relevant polyclonal antibodies (pAbs) and subsequently develop strategies for purification, modification and characterization of these pAbs. The individual will also use a variety of biochemical and biophysical methods to characterize the critical proteins that are produced to support assay development. The individual will cross functionally work to develop a robust HCP program within Regeneron.

Requirements:
  • Ph.D. in Biochemistry, Biology or other relevant scientific field with 0-2 years of industry experience.
  • Technical proficiency in protein affinity purification and ELISA development is desirable.
  • Experience in electrophoresis/immnoblotting techniques, including 2D gels, western blots, WES and/or DIGE is preferred
  • A strong fundamental understanding of protein structure/function and biophysical chemistry is required.
  • Excellent oral and written communication skills are required.
  • Working knowledge or familiarity with HCPs and related issues will be definite plus.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 10833BR