Research Associate II-IV

Location
Tarrytown, New York, US
Posted
May 19, 2018
Ref
10545BR
Discipline
Science/R&D, Research
Required Education
Associate Degree
Position Type
Full time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:
We are seeking Research Associates (levels II-IV) to join the Analytical Chemistry Group of Regeneron Pharmaceuticals Inc. at Tarrytown, NY. The successful candidate will be working in a state-of-the-art mass spectrometry lab and developing top-down and bottom-up mass spectrometry analytical methods for therapeutic protein product analysis. The individual will focus on the biochemical characterization of therapeutic protein at all stages of development, developing LC/MS methods for protein primary structure analysis, disulfide linkage determination, carbohydrate profiling, protein variant structural determination and post-translational modifications. The individual will conduct analytical methods qualification for late stage drug development programs. The individual will also be involved in developing innovative mass spectrometry technologies to support Regeneron's upstream R&D programs.

Responsibilities:
Develops primarily LC/MS based analytical methods to support the development of monoclonal antibody-based therapeutic proteins;
- Conducts analytical experiments on therapeutic proteins, and analyzes mass spectrometry data to elucidate the quality attributes of therapeutic protein candidates and/or products;
- Conducts analytical methods qualification to support the late-stage therapeutic protein development programs;
- Documents experiments, results and findings in laboratory notebook; presents work at the group and department meetings; participates in the writing of technical reports, SOPs, and analytical method protocols, etc.
- Provides data in a quality presentation form (graphs, figures, tables, etc.) to support regulatory submissions and peer-reviewed publications;
- Participates in the general lab and instrument maintenance

Requirements:
- B.S., M.S., or equivalent in analytical chemistry, biochemistry, or proteomics.
- Between 3-8 years of post-graduate experience with good understanding of mass spectrometry principles and their application to protein characterization.
- Previous knowledge regarding proteins/antibodies and experience related to analytical methods.
- Previous hands-on experience with chromatographic separation techniques like reversed-phase, size-exclusion, and hydrophilic interaction chromatography
- Familiar with advanced mass spectrometry technologies like Q-TOF, Orbitrap, Q-Exactive, Triple Quadrupole MS etc...
- Strong organizational and communication skills and effective interpersonal skills.
- Enthusiasm in science with a motivation of making contributions in a team environment.
- Experience in antibody drug or biomarker quantification for PK/PD study is preferred.
- Previous pharmaceutical industry experience is preferred.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 10545BR