Senior Research Associate, Protein Science

South San Francisco, CA
May 17, 2018
Required Education
Bachelors Degree
Position Type
Full time


Harpoon Therapeutics is a biotechnology company located in South San Francisco, CA. We are focused on the development of novel immune cell engaging therapeutics for oncology indications. We are looking for a motivated, flexible, highly productive individual who is seeking a dynamic fast-paced cross-functional collaborative research environment. As an integral member of the Protein Science group, this individual will partner with the New Technologies, Biology Research, and Translational Medicine groups to develop our proprietary platforms. This position is lab based, title commensurate with experience, with the successful candidate primarily engaged in protein purification, analytical, and biophysical characterization experiments.

Key Responsibilities

  • Design and implementation of multi-step orthogonal purification strategies using AKTA Unicorn-based methods
  • SDS-PAGE, spectrophotometry, CE and HPLC analysis of proteins
  • Protein chemistry and analytics of molecules generated toward immunogens, assays, and therapeutic candidates
  • Reagent and consumables inventory management
  • Maintain records, prepare reports, make regular presentations to summarize results and update management

Skills and Qualifications

The ideal candidate will have:

  • A Bachelors, Masters, or equivalent degree in Biochemistry, Protein Chemistry or a related field
  • A minimum of 5 years laboratory experience with a clear understanding of diverse separation strategies and demonstrated ability in protein purification from eukaryotic expression hosts
  • Familiarity with AKTA/Unicorn and Infinity/Chemstation LC systems
  • Enzymology expertise, particularly with respect to characterization of proteases, highly desired
  • Excellent verbal and written communication, strong organizational and interpersonal skills
  • Demonstrated ability to work independently as a rigorous and meticulous experimentalist