Associate Scientist II / Scientist I, Tau

Employer
AbbVie
Location
Cambridge, Massachusetts, USA
Posted
May 17, 2018
Ref
1803684
Required Education
Bachelors Degree
Position Type
Full time
AbbVie has established the AbbVie Cambridge Research Center in Cambridge, MA to investigate the fundamental biological mechanisms and to develop therapeutic interventions for neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. The Tau Biology group is seeking a highly motivated applicant with prior experience and expertise in target validation and assay development in neuroscience.


This Scientist will support a project leader in 1) investigate mechanisms regulating neuron-to-neuron spread and the resulting accumulation of misfolded protein in AD using transgenic animal models and human postmortem tissues, 2) conduct microscopic image-based studies to screen for antibodies and small molecules in neurons.


Key Responsibilities Include:

  • Analyze human AD brain tissues and extract protein of interest using western blot, MSD, and other biochemical assays
  • Culture hiPSC (human-induced pluripotent stem cell) neurons and rodent primary neurons
  • Design and perform tau aggregation inhibition studies in neuronal cultures using confocal microscopy, high-content imaging, high-throughput robotic-assisted imaging. Analyze and present the results to validate novel drug targets.
  • Work diligently and efficiently to meet deadlines in a fast-paced environment.
  • Read and apply relevant scientific literature.
Position will be hired based on level of experience.

  • BS or MS degree in System Neuroscience or related field with 3-5+ (BS) or 0-2+ (MS) years of pharmaceutical industry experience.
  • Proficiency with standard cell biology, biochemistry, and microscopy methods
  • Expertise in developing biochemical and cellular assays for high throughput screening.
  • Familiarity with plate readers and/or high content imaging / familiarity with neuroanatomy is plus but not required.
  • Comfortable using computer programs such as Microsoft, Google Docs, Microsoft Excel, etc.
  • Highly motivated, detailed oriented, curious of the science, and desire to learn to novel neuroscience techniques.
  • Demonstrate critical thinking, independence, clear scientific writing & verbal communication skills and precise record keeping
  • Strong organizational skills that facilitate planning, multitasking and working within timelines.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled