Research Associate II, Cell Genomics Engineering

South San Francisco, CA, United States
May 16, 2018
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Company Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to improve the lives of patients with serious diseases. We have an industry-leading and differentiated drug discovery platform. Our comprehensive proprietary libraries of the extracellular proteome, differentiated screening capabilities and protein therapeutic generation and engineering capabilities comprise a unique and powerful IND engine that will continue to generate important development programs. This uniquely positions us to discover novel pathways and targets in immuno-oncology. Our success with our drug discovery platform has led to a pipeline that is on track to more than double to five development programs in clinical trials across multiple indications in 2018. We also have several undisclosed research programs at different points of the target validation and molecule generation phases that have the potential to yield our next wave of development-stage therapeutic biologics. And we continue to fuel this process at the earliest stages with new screens planned this year.

Five Prime is committed to innovation and outstanding science to develop effective new drugs for the treatment of severe diseases. We value our culture of openness, collaboration and productivity. The company is in a strong financial position and has an effective executive team and Board of Directors. Discover more about FivePrime at

Job Description

We are seeking a highly motivated Research Associate II to join Genomics Cell Engineering group in Biotherapeutics Department. The successful candidate will join our team to develop engineered cells and methods to accelerate development of novel antibody and protein therapeutics and Five Prime. This position reports to Scientist III, Genomics Cell Engineering.

  • Work on cell line engineering projects i.e. developing engineered cell lines for in vitro cell-based assay, implementing engineered cell lines for protein expression, developing knock-out or knock-in cell lines
  • Perform day-to-day laboratory bench work including molecular cloning, cell culture, transfection, limiting dilution, screening cell lines, freezing, thawing cell lines
  • Perform assays to characterize and validate the cell lines and methods
  • Document experimental activities and data analysis in electronic notebook
  • Review experimental data, discuss scientific findings with scientists and team members, troubleshoot experiments and suggest improvements
  • Present project progress in one-on-one and team meetings
  • Other projects and duties as needed


  • B.S or M.S. in biochemistry, molecular biology, cell biology, biochemical engineering, or related discipline with 5+ years of lab experience
  • Experience in mammalian cell culture with excellent aseptic technique
  • Experience and/or good understanding of cell engineering and genome editing technology i.e. CRISPR/Cas9, transposases, recombinases
  • Experience with relevant technique/system is a plus i.e. molecular biology technique, transfection, qPCR, RT-qPCR, flow cytometry and cell sorting, recombinant protein expression system
  • Ability to solve complex problems independently via critical and innovative thinking
  • Attention to detail with good organizational and recording keeping skills
  • Eager to learn and collaborate well with others
  • Excellent written and interpersonal communication skills
  • Diligent, strong growth mindset with positive "can-do" attitude towards assigned tasks

Additional Information

At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.Please call or reply with any comments.

All your information will be kept confidential according to EEO guidelines.