Scientist or Sr. RA for Tumor Immunology
PACT Pharma is an exciting new company in the San Francisco Bay Area. PACT is developing personalized adoptive T cell therapies for the eradication of solid tumors. The identification of neo-epitopes that serve as private mutations for each patient’s cancer creates a unique opportunity to engineer autologous T cells that target and kill tumors expressing these neo-antigens. PACT utilizes technology licensed from the laboratories of Drs. Heath and Baltimore (Caltech) to identify T cells that recognize the neo-epitope. The unique T-cell receptor (TCR) sequences obtained from these neoepitope-reactive cells are then engineered into T cells from the patient’s own blood to produce PACT’s therapeutic product: a tsunami of fresh, active T cells that, following infusion into the patient, recognize and attack each patient’s cancer cells.
We are located in the San Francisco bay area, in the heart of the world’s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including aggressive participation in the growth of the company in the form of stock option grants. PACT Pharma is an ambitious cutting-edge undertaking - we fully anticipate our company to become the world’s leader in personalized adoptive T cell therapies for cancer and therefore key to the future of cancer treatment. Currently located in Hayward, CA but will be moving to another location by year end.
Scientist / Sr. RA – Tumor Immunology
The ideal candidate will be experienced in immunology and T cell biology. She/he will be responsible for the design and execution of critical path experiments for the development of the optimal strategy for the generation of CD3 neoE TCR transgenic cells for adoptive cell therapy (ACT). This research will focus on supporting studies to identifying TCR requirements for optimal functional avidity and the T cell profile for the most favorable homing and longevity. The candidate should enjoy operating in an exceptionally dynamic and cooperative environment.
- The candidate should be highly proficient in state of the art techniques for characterizing T cell receptor binding affinities and kinetics.
- She/he must demonstrate ability in rigorous design and careful implementation of cell-based and biochemical assays.
- She/he must have excellent organizational skills and should be able to communicate clearly and concisely, both verbally and in the form of written reports.
- The ideal candidate will hold a Bachelor degree with 5+ year experience; a Master degree with 2+ year experience; or PhD, with career focus in immunology.
- The ideal candidate will have a deep understanding of T-cell receptor biology and biochemistry.
- The ideal candidate will have experience with assays to evaluate the pMHC-TCR affinity, avidity and dissociation kinetic.
- The candidate will also have experience in generating pMHC reagents (i.e. monomer, pentamer) for these assays
- The candidate should be highly goal-driven and have demonstrated the ability to focus on time-sensitive objectives.
- Industry experience is a plus.