Bristol-Myers Squibb Company

Associate Director Clinial Genomics

Location
Hopewell, NJ, US
Posted
May 12, 2018
Ref
R1120377
Discipline
Science/R&D, Genomics
Required Education
Doctorate/PHD/MD
Position Type
Full time
PRIMARY RESPONSIBILITIES

• Responsible for building and growing internal as well as external (genomic testing providers) genomic testing operations to accommodate organizational needs in a rapidly changing environment.

• Oversees different genomic testing workflows, drives implementation and troubleshooting of various molecular assays in a production environment, including but not limited to PCR, quantitative real-time PCR, digital PCR, NanoString, targeted DNA-seq and RNA-seq, WES, WGS etc.

• Oversees development of experimental plans, validation reports, work instructions, technology transfer documents, study summaries and lab SOPs including: personnel, equipment, assay development, assay validation, clinical sample testing, and technology transfer SOPs.

• Ensures high level of quality and reliability of generated results, administers and enforces implementation of standards for laboratory testing (including GCLP), sets acceptable levels of analytic performance, oversees QC, QA, and QI practices, ensures that standards are consistent with company policies and regulatory standards.

• Oversees development and implementation of Laboratory Information Systems.

• Works with cross-functional teams (internal and external) on the execution of exploratory clinical and translational research projects to address specific scientific questions and/or to test different hypothesis reflecting the BMS portfolio needs.

• Serves as a subject matter expert for genomic technologies, provides guidance on experimental design, method or platform selection, and data management to address a specific need.

• Other assigned duties as required

QUALIFICATIONS

• PhD in molecular biology, genetics and genomics, biochemistry, or other related disciplines

• 5+ years of experience with advanced genomics technologies, preferably including next generation sequencing

• 2+ years of relevant experience directing a clinical laboratory performing high volume high-complexity genetic testing, preferably in an automated laboratory, ideally in a pharmaceutical, biotech or clinical diagnostics industry. Experience working in and leading clinical projects in regulated environments (e.g. CLIA, CAP, GCLP) is highly desired.

• Must have technical expertise and in-depth knowledge of different molecular platforms and technologies, including but not limited to PCR, quantitative real-time PCR, digital PCR, NanoString, Next Generation Sequencing (NGS) etc. Experience with Flow cytometry and Immunohistochemistry is highly desired.

• Must possess documented hands-on (wet lab) experience with molecular assay development, validation, troubleshooting, and reviewing of run QC data. Prior research and development experience in Oncology, Immuno-Oncology and Immunosciences is highly desired.

• Bioinformatics skills, programing in different languages, experience with command line, and familiarity with statistical software packages is highly desired.

• Must have strong organizational and interpersonal skills and project management experience.

• Must display good people skills, demonstrated ability to work collaboratively with others in a highly matrixed environment.

• Must be self-motivated and learn quickly and capable of working independently at times. Must be goal oriented and focused on meeting multiple strict deadlines.

• Thrive in a highly interactive, fast-paced and dynamic team environment.

• Must be able to quickly adapt to changing priorities and work well in fast-paced environment and under pressure.

• Must be fluent in English both oral and written and possess good communication and presentation skills.