Bristol-Myers Squibb Company

Principal Scientist

Location
Redwood City, CA, US
Posted
May 12, 2018
Ref
R1504217
Required Education
Doctorate/PHD/MD
Position Type
Full time
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Summary:

We are seeking a highly motivated and innovative leader who will lead a laboratory group, located in Redwood City, CA to develop and transfer flowchart assays for hit identification, hit triage and Lead optimization. The group will work in close proximity to the Immuno Oncology Resistance Biology (IORB) group in RWC with a mission to identify tumor- and host-mediated mechanisms of resistance to BMS IO assets. This leader will be a member of the portfolio governance team, and will be expected to represent Leads Discovery and Optimization (LDO) capabilities to the project teams as well as represent team and portfolio needs and priorities to LDO leadership/governance. The successful candidate will have a direct reporting relationship with the Vice President of LDO as well as a dotted line reporting relationship to the head(s) of IORB.

Responsibilities:

The successful candidate will have: (a) knowledge and demonstrated a track record to develop and validate high throughput assays (biochemical, cellular, biophysical, other) on cost effective and up-to-date technical platforms, (b) a good understanding of cell signaling in cancer biology and immunology, (c) broad experiences in assay trouble shooting and exploration of new technology platforms to enhance the infrastructure for discovery program support, (d) ability to manage across projects across functional lines and geographic sites/locations, (e) identify and/or innovate new technologies or functional line projects that bring value and efficiency to BMS, (f) represent technical and scientific ideas, as well as project progress/updates to preclinical research teams, IORB portfolio governance, LDO colleagues and leadership/governance, (g) contribute to the development of clinical assays derived from preclinical flowchart assays and contribute to the development of regulatory documents (IND, IB, etc), (h) strong collaborative and written/verbal communication skills and a positive attitude to interact with multiple stakeholders (e.g. therapeutic area teams, Chemistry and Biology leads and outside vendors), and (i) scientific leadership both at the bench and at data analysis.

Qualifications:
  • PhD with minimal 10 years of scientific experience in immunology or tumor oncology.
  • Comprehensive technical expertise in developing and performing diverse in vitro immunoassays with whole blood, T-cells, B-cells, monocytes and macrophages.
  • Hands-on experience with phenotypic screens
  • Hands-on experience with confocal imaging, flow, HTRF, qPCR, and cell based assays
  • Hands on knowledge of contemporary automated platforms used for hit identification and lead optimization instrumentation would be very valuable.
  • Proficiency in designing 384 and 1536 well assays and adept with robotics and lab automation
  • Broad knowledge in compound screening strategy is critical
  • Technology development and implementation experience will be very useful
  • Work with cross-functional project teams to implement automated solutions for assay automation
  • Demonstrated excellence in both written and oral communication and a strong desire to lead in cross functional teams to establish productive collaborations across large portfolios
  • A strong desire to succeed in cross functional teams to establish productive collaborations