Senior Scientist I
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.
More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.
Demonstrate scientific independence to establish and implement strategy for understanding the mechanism of action of drugs and translating it into future therapies for new indications in immune diseases/hematological malignancies.
Design hypothesis-driven proposal and studies of clinical samples to inform clinical responses or mechanism of action of drugs in hematologic cancer such as CLL or non-Hodgkin lymphoma.
Lead hypothesis-generating/testing biomarker studies and collaborate with pre-clinical team to drive studies that inform mechanism of resistance and/or rationales for therapeutic combinations.
Advance science from bench. Design and execute in vitro or ex vivo experiments to determine effect of drugs using flow cytometry through development, optimization, and validation of new assays. Complete all aspects of leukemia-lymphoma immunophenotying, including sample preparation, staining, acquisition, and data analysis.
Apply cell and molecular biology techniques (ELISA, ELISPOT, Luminex, PCR) to identify and evaluate biomarkers using clinical samples. Utilize technical expertise and available information to troubleshoot and resolve key project hurdles if arise.
Actively participate in internal and external scientific meetings by presenting and critically evaluating emerging scientific literature to contribute to projects.
Perform and manage in-house, CRO, or collaborative research to support the development of therapies in a variety of hematological malignancies.
PhD in immunology, oncology, biochemistry, pharmacology, or related fields with zero to 2 years experience as a Post Doc or in industry.
Track record of leading immunology/cancer clinical translational projects.
Strong history of peer-reviewed publications and presentations at national meetings
Expertise in multi-colored flow cytometry is a must. Experience with single cell quantification, cell sorting, and antibody characterization activities.
Experience working with clinical samples; experience in designing and conducting biomarker or mechanistic studies with clinical trial samples.
Knowledge and experience in GLP/GCP standards is preferable.
Experience in establishing SOPs for clinical lab strongly preferred.
Broadly trained in immunology, translational medicine and cancer biology, as indicated by peer reviewed publication in top tier journals and presentation at national and international conferences.
Working knowledge of lymphocyte biology, cell subsets, and lineage markers.