Pharmacokinetics and Drug Metabolism Specialist
The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a specialist to join the pharmacokinetics and drug metabolism group. The director of the IND is Nobel Laureate Dr. Stanley Prusiner. This position will be part of a collaborative environment with access to state-of-the-art facilities in the new Sandler Neurosciences Building on the UCSF Mission Bay campus.
In this role, you will add expertise to the discovery of novel chemical entities (NCE) for treatment of neurodegenerative diseases by developing and carrying out assays to predict and understand pharmacokinetic and drug metabolism profiles. You will be responsible for analyzing samples from pharmacokinetics studies and developing novel formulations for dosing NCEs.
• Specialists appointed at the junior rank must possess a baccalaureate degree in the
physical sciences (or equivalent degree) or at least four years of research experience (e.g., with instrumentation and research equipment such as the MS/MS system and liquid chromatography described below) working on small molecule pharmacokinetics, drug metabolism, pharmacology, or toxicology.
• Specialists appointed at the Assistant rank must possess a master’s degree (or equivalent degree) or five years of experience in small molecule pharmacokinetics, drug metabolism, pharmacology, or toxicology.
• Specialists appointed at the Associate rank must possess a master’s degree (or equivalent degree) or five to ten years of experience in small molecule pharmacokinetics, drug metabolism, pharmacology, or toxicology.
• Specialists appointed at the full rank must possess a terminal degree (or equivalent degree) or ten or more years of experience in small molecule pharmacokinetics, drug metabolism, pharmacology, or toxicology.
• Experience in quantitative analysis on LC-MS/MS systems
• Effective oral and written communication skills
• Applicants must possess these qualifications at the time of appointment.
• Ph.D. with training in pharmacokinetics, pharmacy, pharmacology or a related discipline.
• Candidates with experience in neuroscience and blood-brain barrier permeability are strongly encouraged to apply.
• Experience with metabolite identification, in vitro ADME assays, such as protein binding, microsomal stability, metabolite identification, and transporter assays, and formulating NCE for dosing
• Experience with qPCR, cell culture, western blots, and ELISA for in vitro assay
• Experience with automated liquid handlers for high throughput screening
Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.
UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.