Senior Research Associate - Protein Sciences

94107, San Francisco
May 09, 2018
Required Education
Bachelors Degree
Position Type
Full time

Research Associate/Sr. Research Associate – Protein Sciences

Pionyr Immunotherapeutics Inc., a growing San Francisco Bay area based immuno-oncology company focused on novel approaches to generate anti-tumor immunity, is seeking a qualified Research Associate/Sr. Research Associate who will play an integral role in moving our discovery research efforts into the clinic.   We are seeking a talented and motivated team member to support our research efforts in developing our antibody-based immuno-oncology therapeutics. The candidate should have experience in the characterization of recombinant proteins and monoclonal antibodies, including protein over-expression, purification, and biophysical characterization.

Specific responsibilities include (but not limited to):

·       Development of biosensor (SPR or BLI) based assay platforms for screening/characterization of antibody binding and specificity

·       Biophysical characterization of antibody stability and developability assessment using calorimetry (ITC, DSC), light scattering, and differential scanning fluorimetry (DSF) to support lead candidate selection

·       Organization and analysis of results, communicating and presenting findings in team meetings, and contributing to scientific publications

·       Troubleshooting and optimizing assays through data interpretation, identification of novel or alternate procedures and techniques, and timely execution

·       Ability to work in a team environment and adapt to changing company priorities


·       Bachelor’s or Master’s degree in a life sciences discipline with at least five plus years of industry experience in developing assays using SPR, BLI, DSC, DSF, FTIR, AUC, and DLS

·       Good understanding of biophysical characterization of antibodies is must

·       Experience in standard protein analytical techniques including electrophoresis, Western Blot, ELISAs, HPLC, UV-Vis spectrophotometry

·       Proficiency in protein production and purification techniques (e.g., using peristaltic pumps, HPLC systems), ultrafiltration/diafiltration is a significant plus

·       Motivation to learn and use new and emerging techniques for mammalian cell culture, protein production, flow cytometry, and gene manipulation in cells

·       Excellent communication skills with the ability to work effectively in a dynamic and flexible team environment

·       Ability to maintain detailed records of experimental methods and results

·       Ability to critically interpret and effectively present data

·       Adaptability to shifting priorities and changing work assignments

Piionyr offers competitive compensation and benefits, career development opportunities as well as a dynamic academic science and team based environment.