Scientist, Neuroinflammation

Employer
AbbVie
Location
Cambridge, Massachusetts, USA
Posted
May 08, 2018
Ref
1802241
Required Education
Bachelors Degree
Position Type
Full time

AbbVie has invested in a new research enterprise in Cambridge, Boston - the Foundational Neuroscience Center (FNC). The FNC will investigate the fundamental biological mechanisms underpinning neurodegenerative disease with particular attention to Alzheimer's disease (AD). Pre-clinical, genetic, and bioinformatics studies implicate neuroinflammatory processes as likely contributing factors to Alzheimer's disease onset and progression. Our discovery research team aims to understand how microglia, the predominant innate immune cell type in the CNS, may be therapeutically modulated to improve clinical outcomes in this disease.

We are seeking a cell/molecular biologist preferably with pharma/biotech background to join the neuroinflammation group at the FNC. This individual, with a background in immunology and/or neuroscience , and strong technical expertise in molecular and cell biology, will be responsible for supporting early drug discovery efforts to identify and validate novel drug targets, including assay development and validation, and characterization of model systems to study neuroinflammation and investigate the basic biology behind microglial dysfunction in AD.

Key Responsibilities:

  • Contribute technical and scientific expertise to neuroinflammation project teams

  • Execute on a planned experimental design - collect, analyze, interpret and present data

  • Generate robust and complete data sets to support key Go/NoGo decisions on novel drug targets

  • Work closely with colleagues to initiate high throughput screening assay development

  • Develop expertise with novel technologies and laboratory techniques

  • Lead and/or assist in writing and revising SOPs

  • Work diligently and efficiently to meet deadlines in a fast-paced environment

  • Read and apply relevant scientific literature

  • Adhere to safety and compliance

  • Participate and/or present in internal meetings

  • BS or MS in biology or related field with 5+ years (BS), or 2+ years (MS) of pharmaceutical and/or biotech industry experience
  • Proficiency with cell culture techniques, transfection and transduction methods
  • Proficiency with cellular analytical techniques such as immunofluorescence microscopy or flow cytometry.
  • Skilled with basic techniques such as ELISA, Mesoscale, luminescence
  • Aptitude for basic statistics and software packages such as GraphPad PRISM
  • Demonstrated ability to work well in a collaborative team-oriented environment
  • Demonstrated ability to learn, understand and master new experimental techniques
  • Strong organizational skills that enable multitasking and working within timelines
  • Demonstrated record keeping, scientific writing skills, and strong verbal communication skills

Equal Opportunity Employer Minorities/Women/Veterans/Disabled