Senior Scientist, Translational Pathology-Oncology

Lake County, Illinois, USA
May 08, 2018
Required Education
Bachelors Degree
Position Type
Full time
Develop and drive tissue based biomarker assays including immunohistochemistry (IHC) and in-situ hybridization (ISH) biomarker assay development to support the AbbVie Oncology pipeline. Investigate, identify, develop, and optimize novel methods and techniques for tissue based biomarkers. Act as a lead scientist in his/her area of expertise and critically evaluate relevant scientific advances and integrate this knowledge into research or development programs. As an integral member of the Translational Oncology team, the individual will interface with internal and external biology, genomics/proteomics, in vivo and toxicology teams to deliver translational biomarker assays for novel clinical candidates. Key Responsibilities Include:
  • Lead IHC assay development for chromogenic and multiplex fluorescence platforms.
  • Support target screening to identify biomarkers and indications for clinical development for multiple programs with internal and external collaborators.
  • Integrate complex data sets including DNA, RNA, protein evaluations (various platforms such as microarray, ISH, IHC etc) from preclinical models, procured tissue and patient samples from exploratory clinical trials to support target validation and biomarker development efforts.
  • Collaborate with a diverse set of scientists from histology/pathology, in vivo, molecular biology, cancer biology, biochemistry, protein biochemistry, biostatistics and clinical backgrounds to generate impactful hypotheses for biomarker development.
  • Manage multiple collaborations (internal and external work requests, contracts, etc).
  • Demonstrate the ability to support key project questions/needs by effectively utilizing available information and technical expertise.
  • Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program.
  • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug, GxP compliance, and animal care where applicable.
  • Technical leadership skills to mentor team members and guide and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals.
Grade level and title commensurate with experience
  • Bachelors or equivalent education and 10-12+ years of experience, Master's Degree or equivalent education and 8-10+ years of experience, PhD and typically 0-4+ years of experience.
  • Industry experience is preferred.
  • Expertise in immunohistochemistry assay development is required. It is highly desired to have experience in assay development with automated IHC staining platforms. Experience in chromogenic in-situ hybridization for both DNA and RNA, fluorescent IHC and multiplexing is highly preferred. Familiarity with image analysis, in vitro and/or in vivo assays, genomic data and literature mining, disease/biological pathway analysis, and biomarker development is a plus.
  • Oncology experience in the areas of apoptosis, DNA repair, epigenetics, ADC, biologics therapies, immuno-oncology desired.
  • Good grasp of drug discovery, clinical development, biochemistry, molecular biology, cancer biology and related subjects.
  • Strong communication skills with preparing and presenting data to people with diverse scientific backgrounds required. Excellent interpersonal skills, able to work in a team-oriented environment. Research, scientific and program management experience a plus.
Key Leadership Competencies:
  • Builds strong relationships with peers and cross functionally with partners to enable higher performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.
  • Strong interpersonal and communication skills with demonstrated ability to work within a team environment.