Research Associate

Location
South San Francisco, California
Posted
May 03, 2018
Ref
RAMay18_BM1
Required Education
Bachelors Degree
Position Type
Full time

Maverick Therapeutics is a dynamic start-up that is developing a class of anti-cancer biologic drugs called COBRAs®(conditional bi-specific redirected activation) to induce potent anti-tumor immunity with improved safety.  Founded by leading scientists in the field, Maverick has established a multi-year collaboration with Takeda Pharmaceuticals to bring COBRAs to cancer patients.  We are seeking a talented RA or SRA to join our R&D team.  The successful candidate will serve a key role in the advancement of our lead COBRAs through pre-clinical studies and IND filing.

Responsibilities:

  • Participate in therapeutic programs from target validation through candidate selection and into clinical trials.
  • Core responsibilities include:
  • Develop and qualify immune assays (such as ELISA) to characterize COBRA disposition in vivo, from rodents to humans.
  • Participate in the analysis of preclinical in vivo pharmacology studies including efficacy, pharmacokinetic and biomarker studies, as well as toxicology studies.
  • Participate in translational research studies focusing on patient stratification, biomarker identification, disease indication, and dual targeting strategies
  • Additionally, the successful candidate will
  • Characterize therapeutic candidates in vitro as part of the lead selection process, including target tumor antigen expression, T cell immunophenotyping, T cell dependent cytotoxicity and cytokine release assays.
  • Contribute to the writing of relevant research reports to be included in regulatory filings. 
  • Communicate scientific progress to management.
  • Maintain laboratory notebooks in compliance with Maverick Therapeutics policies.
  • Prioritize group’s efforts to align with and meet or exceed company goals and timelines.

Qualifications:

  • BS/MS in biochemistry, molecular biology, or a related discipline
  • 3+ years of industry experience, preferably in oncology biologics
  • Demonstrated expertise in immune assay development and execution
  • Facility with mammalian cell culture and cell line engineering
  • Deep understanding of concepts relevant to DMPK of large molecules / biologics
  • Proficiency with assay data analysis and reporting; a rigorous approach to record-keeping and data entry is essential

The preferred candidate will also have:

  • Experience with the isolation and profiling of immune cell populations; proficiency in flow cytometry is desirable
  • Experience in supporting IND filings, as through study report writing
  • Excellent presentation skills in team and department settings
  • Strong interpersonal skills