Principal Investigator in Tuberculosis Host-Pathogen Interactions

Saranac Lake, New York
Apr 30, 2018
Required Education
Position Type
Full time

Trudeau Institute, an internationally acclaimed, path-breaking research institute focused on addressing the continuing burden of infectious disease, has an immediate opening for a Principal Investigator at any career stage. The Institute has recently expanded to develop the Trudeau Research Network, consisting of productive, collaborative and strategic inter-disciplinary partnerships, including New York State, biomedical research institutions and private companies, with Trudeau as a hub. Trudeau Research Network features PhD & MD-led teams engaging in multi-disciplinary pre-clinical and clinical research devoted to translating the advances of basic science into new strategies to meet today’s global health challenges.

As a part of our new tuberculosis research center, we are recruiting an innovative cell biologist and/or pathway discovery biologist to lead a research program focused on identifying opportunities for therapeutic intervention in the innate immune control of tuberculosis infection. The Institute is ideally suited for this program with capacious animal facilities, including ABSL-3, maintained by experienced staff. Additionally, the Institute is well-equipped with advanced microscopy and flow cytometry instrumentation, overseen by a dedicated core facility director.

We have a project leader position for creative, experienced candidates with expertise in the interaction of intracellular bacterial pathogens with the host. The successful candidate will lead a group within the Trudeau Research Network, working in a highly collaborative manner with other members of the team, including academic, clinical and industry colleagues. The position will involve a broad range of activities, including experimental research, training and directing junior scientists, interaction with colleagues, participation in grants and contract preparation, networking and presentation of results at meetings and in publications.


-PhD or MD/PhD with evidence of leadership skills and productivity. The candidate should have at least 4 years (early/mid-level position) or 10 years (senior position) of post-doctoral, research staff, and/or comparable industry experience.

-A team player with a desire to contribute to shared aims of a multi-disciplinary research team

-High level of dedication, enthusiasm and commitment to the mission of the Trudeau Research Network

-Interpersonal communication skills, managerial experience

-Excellent written and oral communication skills, ability to network and establish new contacts

-Creativity, initiative, originality (able to think outside the box)

-Proven scientific independence

-Excellent command of the scientific literature, leading to identification of new partners, developing novel approaches and establishing new techniques.

-Breadth and nimbleness- capable of quickly adapting knowledge and skills to addressing new challenges

-Expertise in cellular and molecular approaches to innate immune mechanisms in intracellular bacterial infections

-Experience in cellular and in vivo mechanistic pharmacology

-Skill in quantitative imaging techniques and employing high-throughput functional genomic screens, such as those using Cas9 or RNAi is desirable

-Ability to generate custom mouse models using precision genome engineering approaches, such as CRISPR/Cas9 is desirable

-Experience with pre-clinical animal models and clinical research is desirable

Trudeau Institute is located in an affordable, small town environment in the midst of the beautiful Adirondack Mountains in New York State. On-campus housing situated on a recreational lake is available. We offer competitive salaries along with a robust benefits package (including health, dental, life and long term disability insurance and a generous employer retirement contribution). The Institute is an equal opportunity/affirmative action employer encouraging women, individuals with disabilities