Sr Research Associate II
The Immunology & Inflammation department at Gilead Sciences is seeking an experienced and highly motivated scientist to support therapeutic programs for inflammatory diseases, including RA and SLE. The successful candidate will contribute to discovery of novel candidate drugs, including the design and execution of proof of concept and validation assays. The candidate will assess the mechanism of action of pre-clinical Gilead compounds. He/she will support projects from discovery research into early development as an active member of cross-functional teams. The candidate must be driven, resourceful, and able to work independently and display scientific curiosity and rigor. Excellent organizational skills in management of data, reagents and equipment are essential. The candidate will participate in regular team meetings and present results, interpret data, and formulate conclusions. Teamwork, collaboration with colleagues across disciplines and excellent verbal and written communication skills are critical.
Essential Duties and Job Functions:
• Plans, executes and troubleshoots experiments using appropriately selected methods and techniques to lead and support initiation and/or advancement of drug candidates.
• Participates in immunoassay development and optimization by identifying new technologies that may increase throughput or enhance our understanding of disease mechanisms; stay current with regard to scientific literature and applies knowledge.
• Demonstrates and applies understanding and analytical skills to interpret data and draw conclusions within the broader context of project goals.
• Presents research findings and recommendations to senior staff.
• Ability to work productively in cross-functional teams, demonstrating strong inter-personal skills.
• Works independently with minimal supervision and is able to prioritize a large workload with strong time management skills.
Knowledge, Experience and Skills:
• BS with 5+years or MS degree with 4+years of immunology, inflammation, cell biology or related experience in industry or academia.
• Preference will be given to candidates with a strong background and hands-on experience in experimental immunology/inflammation/cell signaling.
• Technical skills should include: extensive cell culture experience (working with primary cells and cell lines); development and execution of various cell-based assay using small-molecule inhibitors; experience with ELISA, Western blot, Luminex, and qPCR; Familiarity with immunoassay development and optimization as far as cell signaling evaluation; experience with pharmacology studies (pre-clinical animal models). General interest in learning new assays is highly desirable.
• Isolation and manipulation of blood components (human/rat/mouse) is a plus.
• Extensive experience with flow cytometry, including design and execution of multi-color panels and antibody validation is advantageous.
The successful candidate must communicate clearly and effectively to a variety of audiences.
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