Director, Biologics Lead Identification

Employer
Tri-I TDI
Location
Manhattan, Upper East side
Posted
Apr 24, 2018
Required Education
Doctorate/PHD/MD
Position Type
Full time

Director, Biologics Lead Identification

Tri-Institutional Therapeutics Discovery Institute

The Tri-Institutional Therapeutics Discovery Institute (Tri-I TDI) is seeking a highly motivated and enthusiastic individual to provide leadership for biologics drug discovery projects in collaboration with academic investigators. The successful candidate will be responsible for lead identification of therapeutic antibodies and proteins, in order to efficiently advance complex research programs from early target validation through animal proof of concept studies.

The Tri-I TDI, a partnership of Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medicine, links researchers in basic and clinical science with experts in drug discovery from the biotech and pharmaceutical industries, with the goal of more efficiently translating discoveries into therapies for disease.

Position Activities

  • Provide scientific expertise and leadership on biologics drug discovery research programs in collaboration with academic institutions, and support collaborations with biotech, pharma, and CRO partners
  • Coordinate lead identification efforts for biologics drug discovery by overseeing teams and activities for antibody generation, assay development, and screening
  • Lead novel biologics discovery projects at diverse stages ranging from target validation, lead identification, lead optimization and characterization through proof-of-concept studies in disease-relevant models
  • Identify project risks and contingency planning, prepare study/program related materials, and perform other activities associated with research programs
  • Actively represent the Tri-I TDI within the scientific community
  • Reports to the Vice President, Biologics

Education

  • PhD in Immunology, Pharmacology, Molecular or Cell Biology, Biochemistry, or related field

Experience

  • At least 12 years of biologics drug discovery experience in the pharmaceutical or biotech industry
  • An established professional track record of solving complex drug discovery problems, as evidenced by publications or patents

Knowledge, Skills and Abilities

  • Thorough understanding of the biologics drug discovery process from target validation through transition to preclinical development
  • In-depth expertise with antibody generation platforms including hybridoma, single B cell technologies, and phage display
  • Proficiency in developing binding & functional assays and defining screening strategies to enable biologics lead identification
  • Extensive knowledge of in vitro and in vivo pharmacology models coupled with an appreciation for the critical issues ever-present in drug discovery and development
  • Strong interpersonal, collaboration and communication skills in addition to rigorous scientific thinking
  • Highly organized and able to prioritize and handle multiple tasks simultaneously
  • Experience with managing multiple teams of scientists
  • Ability to independently coordinate and monitor collaborations with academic investigators, industry partners, and CROs