Viral Vector Scientist

Location
South San Francisco
Posted
Apr 24, 2018
Ref
Vector Scientist
Required Education
Doctorate/PHD/MD
Position Type
Full time

Job Scientist – Viral Vector Scientist

We are seeking a scientist to lead the development of viral non-viral vectors to engineer lymphocytes to treat human cancers. The candidate will interface between research and product development and will be responsible not just for engineering of the vectors but also for providing key guidance for process development and GMP manufacturing of the vectors moving into the clinic. The successful candidate will have in-depth expertise of retrovirus, lentivirus, and/or AAV viral vector design as well as non-viral vector design and their application for cellular immunotherapies. The position is full time and based in South San Francisco, CA.

Duties and responsibilities:

  • Support design and implementation of a scientific strategy for vector selection and development.
  • Optimize vector cassette and support scale-up production in support of clinical applications.
  • Assist in oversight/management of outsourced vector development and production of clinical trial material.
  • Use in-depth knowledge of vector biology to optimize gene delivery into primary and cultured mammalian cells.
  • Participate in the evaluation of advanced technologies for vector bioprocessing, potential in-licensing opportunities and the identification of external collaborators.
  • The ideal candidate for this position is expected to spend a significant fraction of his/her time in the laboratory leading and supporting the development and production of viral and non-viral vectors.
  • Industry experience in Biotech or Pharma is desirable, but we will consider candidates with relevant academic experience. Experience working with chimeric antigen receptors and adoptive cell therapies is highly desirable.

Candidates must possess:

  • PhD in a related biological science, with post-doctoral training and research experience in the field of virology at the molecular, biological and gene delivery level for cellular immunotherapies. 
  • Minimum of 2-5 years' previous experience working in the development of cell and gene therapies using viral and/or non-viral vectors, preferably in an industry setting.
  • Experience with upstream and downstream bioprocessing of vectors including viral vector biology and cell line development.
  • Experience of working with GMP regulations to manufacture viral vectors for cellular therapies.
  • Experience of cell culture of human and/or mammalian cell lines using a variety of static culture systems and/or bioreactors is essential.

Cero Therapeutics

Cero Therapeutics is a cellular immunotherapy company developing next generation therapies located in San Francisco at the Jlabs biotechnology incubator.

Please contact cero@cero.bio if interested.