Sr. Research Associate, In Vivo Pharmacology

Location
94080, South San Francisco
Posted
Apr 23, 2018
Required Education
Bachelors Degree
Position Type
Full time

SR. RESEARCH ASSOCIATE, IN VIVO PHARMACOLOGY

We are looking for a highly motivated and innovative candidate for the role of Sr. Research Associate, In Vivo Pharmacology. Reporting to the Director, In Vivo Pharmacology, this position is to support discovery teams focusing on identifying small and large molecules for the treatment of cancer, and to contribute to development teams by providing pre-clinical data to support the clinical development plan. The successful candidate is expected to develop and deliver high quality in vivo data in support of oncology target validation, discovery and development projects.

Primary Responsibilities:

  • Design, plan, prioritize, execute, and interpret in vivo studies focused on identifying candidate molecules and translational research within the area of oncology and immune-oncology
  • Manage internal and external (academic and contract research organizations) resources to deliver quality data in an efficient manner
  • Work closely with DMPK, Biology, Translational Medicine, and Project teams to determine key pharmacology questions and seek solutions.

Qualifications & Prior Experience:

  • An M.Sc. with 4+ years or a B.Sc. with 6+ years life sciences experience with a strong focus on in vivo pharmacology/immunology in an industry setting
  • Understanding of key components and process of drug discovery, applied pharmacology and drug development.
  • Strong knowledge of oncology disease processes, disease models, and current clinical treatments.
  • Broad experience on generating in vivo pharmacology data to support the discovery and development of novel cancer therapeutics, including efficacy, tolerability, PK, PK/PD, and biomarker endpoints.
  • Experience in utilizing preclinical cancer models (xenograft, syngeneic and PDX) and applied technologies enabling in vivo analyses.
  • Expert in in vivo skills including animal handling, dosing of small or large molecules (iv, ip, po, and sc), sample preparation, and small animal surgeries.
  • Familiarity with the regulatory requirements to remain compliant with IACUS and AALAC regulations.
  • Hands-on experience in relevant ex vivo experimental and molecular biology techniques such as cell culture, ELISA, qPCR, western blot, and immunohistochemistry; Flow cytometry and cell immunophenotyping is a plus.
  •  Ability to maintain proper scientific documentation associated with pharmacology studies in electronic lab notebooks, write technical reports and present summaries of research results.
  • Strong communication skills and ability to work effectively in a multidisciplinary team environment

About ORIC Pharmaceuticals
ORIC Pharmaceuticals is a clinical-stage oncology company founded by two well-known oncology experts, Charles Sawyers, M.D., and Scott Lowe, Ph.D., who are on the faculty at Memorial Sloan Kettering Cancer Center. Drs. Sawyers and Lowe have done groundbreaking work in cancer treatment resistance, which has resulted in the discovery and development of several novel therapeutics. Richard Heyman, Ph.D., the co-founder of ORIC, was previously co-founder and CEO of Aragon Pharmaceuticals (acquired by Johnson & Johnson after developing ARN509, now apalutamide (Erleada™) and approved for treatment of patients with nonmetastatic castration-resistant prostate cancer) and CEO of Seragon Pharmaceuticals (acquired by the Roche Group after focusing on development of drugs targeting hormone-dependent breast cancer).