Research Associate, Functional Modeling

Location
Tarrytown, New York
Posted
Apr 21, 2018
Ref
13158BR
Discipline
Science/R&D, Research
Required Education
Bachelors Degree
Position Type
Full time
Position Summary

The Regeneron Genetics Center (RGC) is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development.

Summary:
We are seeking a highly motivated Research Associate to join an interactive and fast paced Functional Modeling team at the Regeneron Genetics Center, Tarrytown NY. The successful candidate will support on-going projects modeling human disease variants spanning multiple therapeutic areas. Preferred candidates need to be flexible, motivated and eager to learn. Preferred candidate will possess strong background in molecular and cell biology, biochemistry, and mouse genetics.

Responsibilities:
- Apply current state of the art molecular cloning techniques to construct targeting vectors and expression vectors.
- Proper handling and care of mice, general surgical techniques and collection of blood and tissue samples.
- Perform routine culturing and cloning of mammalian tissue culture cells.
- Perform DNA, RNA, protein extractions; Western blotting; Immunostaining and imaging; PCR and RT-PCR.
- Design, execute, and control experiments according to protocols.
- Develop new methods and apply troubleshooting tactics when needed.
- Perform laboratory calculations and manipulations independently.
- Maintain clear records of experimental details in a laboratory notebook.
- Communicate experimental results, conclusions and ideas directly to supervisor, project team members, and management in presentation form.

We are seeking candidates with a Bachelor or Masters degree in biochemistry, molecular biology, genetics or a related field. Preferred candidates will possess 3-5 years of related laboratory experience.

Candidates should be proficient in molecular biology principles and techniques, including DNA cloning, PCR, sequence analysis, protein expression and purification, and western blotting.

Preferred candidates will have experience with pluripotent stem cell culturing and differentiation assays.

Proficiency with sequence analysis software (MacVector, Sequencher) and genomic sequence databases is preferred.

Candidates must be able to work on multiple projects simultaneously and be able to adapt quickly to changes in priorities.

Candidates must interact effectively with fellow scientists and research associates and to maintain a high level of productivity as a team player in a fast-paced collaborative environment.

This position will require the individual to pass a physical before beginning employment.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 13158BR