Research Associate - Bioassay Development and Antibody Screening

Tarrytown, New York
Apr 20, 2018
Required Education
Bachelors Degree
Position Type
Full time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

The bioassay development group in the Therapeutic Proteins Department seeks a highly motivated Research Associate to join a fast-paced, dynamic group involved in assay development and high-throughput screens in early drug development. The candidate should expect 70-80% of benchwork, involving but not limited to cell culture work, FACS, common molecular biology (eg. cloning) and biochemistry (eg. ICC and WB) techniques. The rest will be mainly on data recording (ELN) data analysis/organization. There will also be numerous chances for both intragroup and intergroup presentations. Responsibilities include, but are not limited to:

• Develop and perform cell-based or enzymatic assays to test the function of a therapeutic target proteins based on its mechanism of action in support of the company's Velocimmune antibody pipeline

• Learn about target biology, identifying strategies to interrogate the molecular mechanism and developing assays that can be used for testing in-vitro function of the protein to identify/characterize potential drugs

• Perform mammalian cell culture, generation and characterization of cell lines
  • o Transfection and transduction
  • o Stable cell line generation
  • o Flow cytometry and immunocytochemistry, immunoblotting, high content screening
• Develop and optimize cell-based bioassays such as luciferase, calcium flux, viability, etc and enzymatic assays
• Perform high-throughput screens using 96- and 384-well formats
• Analyze data, trouble-shoot experiments, and meet timelines
• Record experiments in electronic notebook accurately in a timely manner
• Communicate results to supervisor concisely and effectively

Bachelors degree in biology or a related field with 4+years experience or Masters degree in biology or a related field with 1+year experience. The ideal candidate should have a strong background in cell biology/ biochemistry/ molecular biology and demonstrate scientific curiosity and technical proficiency. Experience developing cell lines and cell-based assays is highly desirable. The ability to work collaboratively, multi-task with attention to detail and organization, and communicate well both within the group and across groups is essential.

Level will be commensurate experience.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 13076BR