Scientist I, Analytical Development

South San Francisco, CA, United States
Apr 16, 2018
Biotech Bay
Required Education
Position Type
Full time
Company Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to improve the lives of patients with serious diseases. We have an industry-leading and differentiated drug discovery platform. Our comprehensive proprietary libraries of the extracellular proteome, differentiated screening capabilities and protein therapeutic generation and engineering capabilities comprise a unique and powerful IND engine that will continue to generate important development programs. This uniquely positions us to discover novel pathways and targets in immuno-oncology. Our success with our drug discovery platform has led to a pipeline that is on track to more than double to five development programs in clinical trials across multiple indications in 2018. We also have several undisclosed research programs at different points of the target validation and molecule generation phases that have the potential to yield our next wave of development-stage therapeutic biologics. And we continue to fuel this process at the earliest stages with new screens planned this year.

Five Prime is committed to innovation and outstanding science to develop effective new drugs for the treatment of severe diseases. We value our culture of openness, collaboration and productivity. The company is in a strong financial position and has an effective executive team and Board of Directors. Discover more about FivePrime at

Job Description

We are currently seeking a highly motivated individual to join our Analytical Development group. This position will be responsible for leading the development of our mass spectrometry assays for several pre-clinical and clinical programs. Additionally, the successful candidate will also provide support to research and development groups in gaining a deeper understanding of the proteins produced for early stage testing. The scientist will also leverage their background to implement new technologies that can accelerate program timelines. The position reports into the biophysical/biochemical assay development group within Analytical Development.

Responsibilities include but are not limited to:
  • Develop mass spectrometry assays to support protein characterization efforts for clinical and pre-clinical programs
  • Design and execute studies to increase the understanding of candidate molecules
  • Work with other Process Development functional groups to ensure program timelines are kept
  • Author reports for analytical characterization and technical transfer
  • Provide expert guidance to research groups on assay design
  • Other projects when assigned


  • A PhD degree in biology, biochemistry, chemical engineering, or a related discipline with 0-2 years of laboratory research experience in industry
  • Extensive experience working on protein mass spectrometry assays, particularly peptide map and intact mass is required
  • Experience transferring assays to contract laboratories is a plus
  • Highly motivated, flexible, and multi-tasks
  • Excellent written and interpersonal communication; ability to influence and collaborate in a team environment
  • Analytical and excellent problem-solving skills

Additional Information

At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.Please call or reply with any comments.

All your information will be kept confidential according to EEO guidelines.