Scientist I, Cell Genomics Engineering

South San Francisco, CA, United States
Apr 16, 2018
Biotech Bay
Required Education
Position Type
Full time
Company Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to improve the lives of patients with serious diseases. We have an industry-leading and differentiated drug discovery platform. Our comprehensive proprietary libraries of the extracellular proteome, differentiated screening capabilities and protein therapeutic generation and engineering capabilities comprise a unique and powerful IND engine that will continue to generate important development programs. This uniquely positions us to discover novel pathways and targets in immuno-oncology. Our success with our drug discovery platform has led to a pipeline that is on track to more than double to five development programs in clinical trials across multiple indications in 2018. We also have several undisclosed research programs at different points of the target validation and molecule generation phases that have the potential to yield our next wave of development-stage therapeutic biologics. And we continue to fuel this process at the earliest stages with new screens planned this year.

Five Prime is committed to innovation and outstanding science to develop effective new drugs for the treatment of severe diseases. We value our culture of openness, collaboration and productivity. The company is in a strong financial position and has an effective executive team and Board of Directors. Discover more about FivePrime at

Job Description

We are seeking a highly motivated Scientist I to join Genomics Cell Engineering group in Biotherapeutics Department. The successful candidate will be a key contributor in a highly collaborative and fast-paced environment. The person will provide his/her expertise and support to develop engineered cells and methods to accelerate development of novel antibody and protein therapeutics at Five Prime. This position reports to Scientist III, Genomics Cell Engineering.

  • Develop next-generation CHO host cell lines for manufacturing i.e. engineering cells to express recombinant proteins with desirable protein yield and product quality
  • Provide expertise and support, and be a liaison between research and development for cell line engineering projects i.e. developing engineered cell lines for in vitro cell-based assay, implementing engineered cell lines for protein expression, developing knock-out or knock-in cell lines
  • Collaborate with other groups in biotherapeutics (Molecular Biology, Protein Chemistry & Antibody Engineering) and Manufacturing Sciences departments to contribute to team goals on assigned projects
  • Perform day-to-day laboratory bench work, analyze and interpret the data, document experimental activities and data analysis in electronic notebook
  • Present and communicate the findings and project status in one-on-one and team meetings
  • Maintain up-to-date knowledge of the recent findings in the field
  • Other projects and duties as needed


  • Ph.D. in biochemistry, molecular biology, cell biology, biochemical engineering, or related discipline with 0-2 years of experience
  • Substantial knowledge and experience in cell engineering and genome editing technology i.e. CRISPR/Cas9, transposases, recombinases
  • Experience with mammalian cell culture and recombinant protein expression systems, especially stable expression
  • Experience with antibody or Fc-fusion protein expression is a plus
  • Experience with relevant technique is preferred i.e. molecular biology technique, transfection, qPCR, RT-qPCR, flow cytometry and cell sorting
  • Good understanding of related processes/technologies is desirable i.e. molecular biology, bioreactor process, protein purification, in vitro cell-based assay
  • Excellent interpersonal communication and written skills
  • Collaborate effectively in multi-disciplinary team and cross-functionally
  • Ability to solve complex problems independently via critical and innovative thinking
  • Great presentation skill and effectively communicate scientific findings via one-on-one discussions and in team meetings

Additional Information

At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.Please call or reply with any comments.

All your information will be kept confidential according to EEO guidelines.