Scientist, Functional Genomics

Employer
AbbVie
Location
Lake County, Illinois, USA
Posted
Apr 13, 2018
Ref
1802809
Required Education
Bachelors Degree
Position Type
Full time
AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie is committed to the discovery and development of new medicines that make a remarkable impact on the lives of patients.
Job description: The AbbVie Discovery organization is seeking to hire a Functional Genomics Scientist within the Genomics Research Center in the Target Enabling Science and Technology Department. We are looking for an experienced laboratory research scientist to perform CRISPR/Cas9 functional genomics research based on lentiviral and RNP delivery methods. The successful candidate will participate in cross-functional target identification and validation projects to support early drug discovery efforts in oncology, immunology, immuno-oncology, and neuroscience. S/He will develop cell-based functional assays using cell lines and primary cells, perform arrayed (384-well plate) and pooled CRISPR screens, using fluorescent cell sorting or high content imaging assays, and analyze screening data using various bioinformatic and statistical software. S/He will collaborate extensively with scientists across diverse functional and therapeutic areas in matrix research environment.
Position will be hired based on level of education and experience.
Qualifications:
  • B.S. or M.S. in cell and molecular biology, or in a related discipline, with 5+ (BS) or 3+ (MS) years of experience in laboratory research
  • Extensive experience in cell-based functional assay development required.
  • Experience with IPSCs and IPSC-derived cellular models required.
  • Strong skills in molecular analytic methods including DNA/RNA isolation, PCR primer design, molecular cloning, genotyping, qPCR, and western blot are required.
  • Basic conceptual understanding of broad genomic technologies such as next-generation sequencing, RNA Seq, RNAi (shRNA/siRNA), and CRISPR gene editing is required.
  • Experience in transfection, nucleofection, lentiviral transduction, flow cytometry and primary cells desired.
  • Candidates experienced in HTS lab automation, liquid handling, or high-content cell imaging analysis desired.
  • Ability to learn new skills and apply them in a fast-paced research environment is a must.
  • Demonstrated creativity, problem-solving skills, and attention to details are required.
  • Strong communication and collaboration skills are desired. Ability to work independently as well as in a team is a must.
Key Leadership Competencies:
  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled