Scientist (Formulation Development)

Location
Tarrytown, New York
Posted
Apr 13, 2018
Ref
12998BR
Required Education
Associate Degree
Position Type
Full time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:

Scientists in the Formulation Development Group of Regeneron Pharmaceutical Inc. located in Tarrytown, NY; work in a state-of-the-art laboratory developing formulations for protein-based drug products and provide support to research, pre-clinical, clinical and manufacturing teams to move drugs from candidate selection and preclinical development to clinical development and commercialization. Individuals are responsible for carrying out and overseeing protein formulation development and stability testing including lyophilized and liquid formulations, and interacting extensively with cross-functional development teams. In addition, scientists carry out research on protein formulation development, protein stability and characterization, and analytical method and new technology development.

Technical/Leadership Responsibilities:
  • Leads and participates in development and stability assessment activities that may include candidate screening and selection, developing lyophilized or liquid formulations for preclinical and Phase 1 clinical studies, and developing liquid formulations for Phase 2/3 clinical studies and commercialization including assessment and selection of primary container closure system such as pre-filled syringes. This is a technical position and the successful candidate will spend a large percentage of their time in the laboratory conduction experiments and studies.
  • Directly or indirectly leads, guides, and works with Research Associates in conducting research and developmental work, and investigating and solving developmental problems. Sets goals, assigns tasks, and provides performance management and development as needed.
  • Independently designs, writes, executes and documents stability studies and other experiments to support stability testing and understand quality attributes to support formulations and stability
  • Develops and uses analytical methods to support formulation development and stability testing of lyophilized, and high-concentration liquid monoclonal antibody formulations
  • Seeks out, recognizes and assesses new technologies to improve formulation development and stability testing
  • Presents work at group, department and inter-department meetings, serves as a team representative in drug development team meetings, and shares knowledge and expertise of formulations development at cross-functional team meetings
  • Authors and reviews formulation development sections of regulatory and technical documents, study reports and technology transfer documents
  • Participates in general lab and instrument maintenance.
  • Keeps updated on latest scientific findings by reading peer-reviewed science journals, and attending and presenting at relevant scientific conferences

Qualifications:
Ph.D. in chemistry, biochemistry, pharmaceutical sciences and pharmaceutics (or related discipline) with an additional 1-3 years of experience, and a proven track record of publications in the field. Post-doctoral experience is preferred but not required.
  • Expertise in protein chemistry/biochemistry and characterization, with keen analytical and problem-solving skills are a must. Expertise in protein stability, chemistry, structure or biophysics is highly desirable. Experience with rheology is also highly desired.
  • Hands-on experience and trouble-shooting proficiency with chromatographic (HPLC, UPLC, column chromatography) and/or biophysical techniques (UV-vis, CD, FTIR, DSC, Fluorescence, particle analysis, etc.).
  • Working knowledge of statistical software for data analysis using JMP, Minitab, Prism etc. is preferable.
  • Excellent oral and written communication skills are required.
  • Should be hard working, detail oriented, be able to recognize subtle trends in data, and possess an ability to grasp the big picture.
  • Enthusiasm in science with a motivation for making contributions in a team environment is necessary.


This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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Requisition Number: 12998BR