Associate Director Protein Biochemistry

Location
Tarrytown, New York
Posted
Apr 13, 2018
Ref
12945BR
Discipline
Science/R&D, Chemistry
Required Education
Doctorate/PHD/MD
Position Type
Full time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Overview

The Protein Biochemistry organization, with staff located in Tarrytown, NY, provides biochemical and biophysical characterization of candidates in support of moving biotherapeutic drugs from late stage research through first-in-human studies. The associate director/senior director will manage a group within the protein biochemistry organization and be technically responsible for biochemical and biophysical characterization of protein-based drugs and protein reagents to support drug candidates in the drug development pipeline as well as develop assays to support regulatory requirements for pre- and post-approval.

Primary technical responsibilities include the biophysical developability of lead candidates in research, development of characterization methods, characterization support for initial GLP toxicology studies, and extended characterization of biotherapeutics to support IND filings. The candidate will also be responsible for managing the performance and career development of direct reports, serving on or leading cross-functional teams, writing and reviewing technical documents and regulatory submissions, developing analytical strategy, and communicating technical information to appropriate groups and management.

Essential Job Responsibilities

• Supervises and mentors a group with accountability for individual performance management (i.e., setting goals and expectations, conducting performance reviews).
• Together with protein biochemistry senior leadership team, provides high-level vision related to protein therapeutic characterization and develop analytical strategy to ensure group is meeting industry standards and trends and brings an understanding of regulatory direction.
• Guides technical development of biochemical and biophysical assays. Participates and/or leads cross-functional development teams and effectively communicates information to appropriate groups, staff, and supervisor.
• Reviews technical documents and regulatory submissions. Reviews publications in peer-reviewed journals, when appropriate.
• Consistently demonstrates excellent written and verbal communication skills and the ability to work in cross-functional team environment.
• Seeks and fosters collaboration and clear communication within protein biochemistry and key cross-functional stakeholders.

Other Job Responsibilities

• Guide efforts to support initial toxicology studies.
• Guide efforts to maximize operational effectiveness of the laboratory including continuous improvement in work practices, testing procedures, and employing compliance when appropriate.
• Guide efforts to develop new cutting-edge technologies for improving efficiency or increasing depth of biochemical and biophysical characterization of biotherapeutic candidates.
• Assist in transfer of methods to Regeneron's Quality Control group and external partners, when appropriate.
• Ability to thoroughly analyze/understand results and methods, solve analytical problems, troubleshoot assays and meet regulatory expectations for analytics.
• Maintain effective communication with groups within R&D, regulatory
• Ability to manage resources effectively to complete corporate deliverables on time.

Qualifications

• Graduate degree (PhD) or equivalent in biochemistry, biophysical chemistry, or related field with +8 years of progressive industrial experience is required.
• Experience in supervising a group with accountability for individual performance management (i.e., setting goals and expectations, conducting performance reviews) is required.
• Experience leading technical teams, drafting technical documents and supporting CMC regulatory filings, and publishing in peer-reviewed journals are required/
• Excellent written and verbal communication skills and the ability to work in a cross-functional team environment are critical.
• Strong scientific background in protein analysis with hands-on laboratory experience in the biochemical or biophysical characterization of proteins is required.
• Experience in developing analytical methods, characterizing monoclonal antibodies or other proteins, and strong working knowledge of protein characterization techniques are required.
• Hands-on laboratory experience with liquid chromatography (FPLC, HPLC, and UPLC), static and dynamic light scattering, capillary and gel-based electrophoresis, and spectroscopic techniques (fluorescence, CD, FTIR, Raman, DRS, SINS, SANS/SAXS), in silico-based modeling are highly preferred.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

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Requisition Number: 12945BR