Senior Research Scientist
A Research Scientist in the Department of Immuno- and Molecular Toxicology will be responsible for designing, justifying, developing, implementing, and performing various immunologic, biochemical, and molecular biology-based assays that address the toxicologic, immunomodulatory and/or immunogenic potential of compounds in development. In addition, the qualified candidate will participate on investigative project teams aimed at addressing key scientific and/or project-related questions including mechanistic toxicology concerns across the portfolio. This position involves evaluation of recent literature and new technology, assessment and implementation of new experimental techniques/approaches, significant problem-solving efforts, as well as presentation and defense of experimental approaches and data to colleagues and management.
- Play a key leadership role in the design, development, validation, and conduct of immunologic, biochemical, and molecular biology-based assay systems that address the immunomodulatory and/or immunogenic potential of compounds in development, as well as assays to investigate mechanisms of toxicity across the portfolio. As appropriate, this person communicates and defends results of experimental testing in presentation formats, meetings, internal reports and/or external publications.
- Design and develop laboratory procedures/assays to support programs across the portfolio, establish procedures for experimental techniques, and conduct laboratory procedures/assays in compliance with established protocols, often according to regulatory and standard laboratory requirements. This person will use a broad range of experimental platforms including ex vivo or in vitro analysis of the function/phenotype of a variety of cell types, cell culture, multiplexing technology, flow cytometry, polymerase chain reaction, a variety of molecular biology techniques, ELISA platforms and many others, as appropriate.
- Share scientific expertise across departments to facilitate successes in drug development portfolio wide.
- Prepare or revise test methods and standard operating procedures and maintain equipment under guidelines set forth by SOPs and, when appropriate, GLP regulations.
- Play a key role in group laboratory meetings and participate in data analysis and interpretation/summary discussions, and troubleshooting of technical issues initiated by self and colleagues.
- Maintain study notebooks, compiles data, and details written experimental instructions, particularly in areas involving new technology and/or novel experimental approaches.