Bristol-Myers Squibb Company

In Vivo Pharmacology Scientist III / Senior Scientist

Location
Redwood City, CA, US
Posted
Apr 12, 2018
Ref
R1503908
Required Education
Doctorate/PHD/MD
Position Type
Full time
The successful candidate will join the Pharmacology Department in the Oncology Discovery Research team at Bristol-Myers Squibb in Redwood City, CA and aide in the advancement of early to late stage therapeutics in immune-oncology and oncology.

The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will evaluate efficacy, mechanism-of-action, PK/PD, toxicity of novel therapeutics in rodent models and write technical reports and pharmacology section for IND submission. The candidate must have the ability to interact closely with PI's to design in vivo efficacy and mechanism-of-action studies. Strong data analysis and study design/statistics knowledge is essential. In vitro assay experience with strong working knowledge of flow cytometry as well as a variety of immune and tumor cell functional assays is needed. The candidate will organize, design, and assign studies to his/her team. Good interpersonal, communication, leadership and mentoring skills. I Experience running a team is essential. Ability to present data to large and diverse teams, broad and deep understanding of pharmacology and immuno-oncology and appropriate models leading to oncology drug development. The candidate will be expected to effectively collaborate with colleagues in the oncology, immunology, immuno-oncology, protein engineering/antibody development, medicinal chemistry, PK/PD modeling, toxicology, biomarker and clinical groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.

Qualifications

PhD with 5 to 10 years of relevant industry experience and a clearly demonstrated skill set in pharmacology, oncology, immuno-oncology, or immunology is required. Attention to details with excellent leadership, organizational and record keeping skills is a requirement. Excellent interpersonal skills with the ability to interact effectively with people, internally and externally is required.

Responsibilities include
  • Work closely with project teams and leaders and determine key Pharmacology questions
  • Design, execute and analyze mouse tumor efficacy studies
  • Conduct in-life phase of PK/PD mouse studies, CBC, blood flow, cytokine profiling in circulation and tumors
  • IM, TIL profiling when needed
  • Develop PD/biomarkers in mouse tumor models and determine target engagement
  • Develop and conduct in vivo DC, NK, T cell function assays in addition to efficacy endpoints
  • Accurately maintain proper scientific documentation associated with pharmacology studies in electronic lab notebooks, and write technical reports and pharmacology summary for IND submission.
  • Ability to effectively communicate and present summaries of research results to team members or to a multidisciplinary team of researchers.
  • Work as a member of a diverse and motivated team of researchers spanning across multiple divisions of oncology discovery and development units.