Molecular Biologist - Genome Editing in Mosquitos & Malaria Parasites
Sanaria is a biotechnology company based in Rockville, MD, dedicated to the development, manufacture, clinical testing and deployment of whole sporozoite vaccines to protect individuals against malaria infection and eventually for focal elimination of malaria from geographical areas. As part of this effort, Sanaria is utilizing genome editing technologies, specifically CRISPR/Cas9, to:
1. Knockout immune genes in mosquitoes in order to make them highly susceptible to Plasmodium falciparum infection and thereby improve the efficiency of our vaccine manufacturing process.
2. Construct genetically modified Plasmodium falciparum strains for the development of our next generation vaccines.
Sanaria offers a unique and challenging opportunity for a molecular biologist to join a world-class team to work on the development and commercialization of our live sporozoite-based malaria vaccines. We are seeking a highly motivated, creative, hard-working, and enthusiastic individual with hands-on experience in CRISPR/Cas9 technology and molecular genetics. An initial responsibility will be the design and selection of guide RNAs, construction of donor DNA plasmids, and molecular characterization of mutant mosquito lines. Experience in molecular and cellular techniques essential for gene expression studies of constructed mosquito and parasite lines is required. The candidate will be an integral part of an in-house team of accomplished molecular biologists, parasitologists and entomologists and an expanding collaborative team that currently involves the Insect Transformation Facility at the University of Maryland Institute for Bioscience and Biotechnology Research and the University of Leiden (the Netherlands), and external consultants. The candidate will participate in GMP manufacturing of Sanaria’s malaria vaccines.
Qualified candidates are expected to have Ph. D with a minimum of 3 years postgraduate experience in molecular biology and genome editing. Experience in mosquito or parasite biology and insect or parasite genetic transformation would be optimal. Excellent communication, writing, teamwork and organization skills and the willingness to learn new experimental and operational techniques are essential. Authorization to work in the US without sponsorship is required.
We offer a competitive salary and benefits package. To apply, please send cover letter, resume and salary history. For more information, please visit www.sanaria.com.
Sanaria Inc. is an equal opportunity employer.