Research Manager I - Immunology & Cell Biology
Summary of Position
The Research Manager I is responsible for characterizing biologic drug candidates by performing in vitro cell-based bioassays/experiments in the field of immunology, cell biology and oncology, analzying data, and providing interpretations, recommendations and conclusions in a timely and accurate manner. This individual will aslo work closely with other functional groups to provide technical support for processing and analyzing patient blood samples from early phase clinical immunotherapy trials.
Responsibilities and Job Duties
- Designs and performs cell based immuno assays/experiments, and ensures data quality and timely execution.
- Seeks to understand the broad objectives of the project as well as individual role in achieving those objectives, and modifies experimental plan when required to respond accordingly.
- Analyzes research data accurately and interprets research results to answer scientific questions
- Authors assay protocols and experimental procedures incorporating scientific rationale and necessary technical information for assay development, scientific publications and IND submissions
- Provides logistical support to cell biology group for troubleshooting common immunological bioassays
- Operates immunological laboratory instruments including flow cytometer, fluorescent plate reader and cell sorter, and responsible for ensuring the instruments are properly maintained and for notifying the appropriate service providers to provide regular maintenance and/or repair the equipment in a timely manner.
- Learns, understands and masters new experimental techniques, and act as a technical resource for the team and other cross functional groups.
- Provides technical and scientific support to other research teams on the processing and handling of human blood samples from early phase clinical immunotherapy trials.
Education & Experience
- Bachelors degree in Cell Biology, Immunology or Molecular Biology or biomedical science discipline and a minimum of 10 years of directly related experience; or
- Master’s degree in Cell Biology, Immunology or Molecular Biology or biomedical sciences discipline with 5 years of directly related experience
- Recent experience with human tumor cell line maintenance, PBMC and major lymphocyte population (T, B and NK cells) isolation from human peripheral blood, flow cytometer-based immunophenotyping, culture of human or murine lymphocytes and cell proliferation assays as well as ELISA is required
Knowledge, Skills and Abilities
- The individual should be well versed in various analytical methodologies including but not limited to flow cytometry, immunospot, ELISA, and MSD
- Excellent mammalian cell or cell line culture skills
- Knowledge of human and rodent immune cell purification and manipulation
- Knowledge of cell based binding assays, CTL and intracellular staining methodology
- Excellent record keeping, organizational, written and verbal skills
- Familiar with routine immune functional assays for human or murine immune cell populations
- Able to set up assays and conduct technical troubleshooting analysis
- Able to analyze data and provide a critical interpretation of results
- Work in collaborative way with other members of the highly productive team and research groups
- Ability to handle multiple priorities in a fast-paced environment
- Strong interpersonal skills for interfacing with other functional groups
Not required at this time
- Work experience in biotechnology and/or pharmaceutical companies
- Strong experience in human or murine B cell, T cell, NK cell and antigen presenting cell functional assays preferred
- A strong background and training in cell biology, oncology and immunology
- Hands-on operation experience on various instrumentation include flow cytometry, luminex, MSD, plate reader etc.