Scientist I, Biochemistry and Molecular Pharmacology

Employer
Celgene
Location
Cambridge, MA
Posted
Apr 02, 2018
Ref
1800906
Required Education
Bachelors Degree
Position Type
Full time

Other Locations:US- MA- Cambridge


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

The Biochemistry and Molecular Pharmacology Department at Celgene Cambridge is seeking a highly motivated biochemist for a Scientist I position.  The incumbent will work on expression and purification of recombinant proteins and perform biochemical and biophysical assays to support our drug discovery efforts.  The successful candidate should have a B.S. degree with at least 10 years, a M.S. degree with at least 8 years, or a Ph.D. degree with at least 2 years of experience in biochemistry or a related field.

Responsibilities:

  • Design and assemble vectors for recombinant protein expression

  • Express protein in E. coli, insect, and mammalian cells

  • Perform small to mid-scale protein purification

  • Work with CROs on large scale protein expression and purification

  • Characterize basic biochemical and catalytic properties of recombinant proteins

  • Carry out biochemical and biophysical assays to characterize small molecule inhibitors of drug target proteins

  • Analyze and report results to the corporate database and project teams

Technical Skills:

  • Broadly trained in molecular biology and biochemistry techniques

  • Experience with the design of vectors appropriate for recombinant protein expression in E. coli, insect cells (utilizing baculoviral vectors), and mammalian cells

  • Expertise in protein purification using FPLC and equivalent chromatography systems

  • Hands on experience in plate-based biochemical and biophysical assays

  • Ability to generate precise, reliable data and skillfully analyze the data essential

  • Experience with surface plasmon resonance (SPR) a strong plus

Other Attributes:

  • Function independently within project teams

  • Reliably execute on team responsibilities in a timely manner

  • Strong communication and organization skills

  • Highly self-motivated & fueled by a fundamental interest in contributing to science in general, and drug discovery in particular

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.