Scientist/Sr Scientist in Analytical R&D
About Ascendia Pharmaceuticals:
Ascendia is a specialty pharmaceutical company dedicated to developing enhanced formulations of existing drug products, and enabling formulations for pre-clinical and clinical stage drug candidates. Ascendia specializes in creating formulations for poorly-water soluble molecules using nano-particle technologies. Ascendia assesses the feasibility of a broad array of formulation options to improve a drug’s bioavailability and solubility. Ascendia’s technologies include nano-emulsions, amorphous solid dispersions, nano-particles, injectable, and oral controlled release. Ascendia provides development and testing services – from discovery-stage molecules to life-cycle-management projects - creating formulation solutions with enhanced biopharmaceutical properties suitable for clinical scale-up.
The mission of our company is to provide customized formulation solutions to “salvage” difficult compounds and to create advanced medicines to help patients “prevail” over their disease and enhance quality of life.
About the Position:
The qualified candidates will take an active role in supporting drug development by applying a variety of analytical methodologies to support physical and chemical characterization of drug substances (including raw materials and intermediates) and drug products. Experience in polymer, large molecule and nanoparticles characterization such as size-exclusion chromatography (SEC) or gel permeation chromatography (GPC), light scattering, and ion chromatography (IC) is highly desired. Working knowledge of other analytical techniques (e.g., particle size, dissolution, FTIR, GC, CAD, LC-MS) used for the characterization of pharmaceutical substances and products is desired.
The individual will be responsible for performing laboratory work in support of analytical testing of pharmaceutical projects, and relevant experience with the following analytical methodologies: chromatography (SEC/GPC and IC), dissolution, KF, or particle size will be desirable. Job responsibilities may include analytical method development and validation; stability and release testing; testing to support pharmaceutical development efforts; direct interaction with project team members, including presentation of data; critical review of data; preparation of technical reports; and evaluation of new instrumentation or analytical techniques. The candidate must be able to interact effectively with peers and leaders as part of a multi-disciplinary team and work in a fast-paced environment. Attention to detail, strong organizational skills, the ability to multitask, and effective interpersonal and communication skills are required.
The position requires a B.S., M.S., or Ph.D. in Pharmaceutical Chemistry, Analytical Chemistry, Chemistry, or Pharmaceutical Sciences.
Experience in size-exclusion chromatography (SEC) or gel permeation chromatography (GPC) for polymer testing and ion chromatography (IC) is required.
Working knowledge in analytical method development or validation under cGMP environment.
Experience with a wide-variety of software and information systems (e.g. Empower, ChemStation, or LIMS).
Good oral and written communication skills and the ability to write and review technical reports and scientific papers are desired.
Working knowledge of pharmaceutical product development, CMC regulatory requirements, project management; and capability to collaborate with colleagues.
Please visit our website at www.ascendiapharma.com for more information. To apply, please submit your CV or resume.