Sr. Research Associate, Biologics Formulation Development

Location
94158, San Francisco
Salary
Based on Experience
Posted
Mar 28, 2018
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time

Position Summary:
Participates in developing formulations for stable and releasable PEG-protein therapeutics.   Designs and conducts pre-formulation and formulation development studies for parenteral liquid and lyophilized biologic drug products to ensure stability and manufacturing feasibility for pre-clinical and clinical trials.  This position contributes to and supports the company’s research and product development efforts to create high value therapeutics to address unmet medical needs.

Responsibilities:
Responsible for design and development of new biologics drug formulations. Also responsible for formulation optimization with a view to establish the quality and stability of drug products. General responsibilities include:
• Design and conduct biologics formulation development experiments, either independently and / or in a collaborative environment.
• Perform sample analysis with biochemical and biophysical assays including HPLC, CE-SDS, cIEF, KF, particle analysis.
• Write experimental plans / protocols and technical reports  
• Accurate and timely documentation of scientific work; analysis, interpretation and preparation of data for presentation; assist in generating technical reports.
• Assist in maintaining general laboratory functionality and safety, including ordering/receiving lab supplies and lab equipment maintenance.
• Other relevant duties

Requirements:
• Bachelors or Masters degree in a related scientific or engineering discipline. Equivalent experience may be accepted.
• A minimum of 6-8 years of work experience in research and/or development environment, preferably in bioassay, biochemistry or biologics formulation develoment (6 years for Masters and 8 years for Bachelors.)
• A solid understanding of protein chemistry, degradation / stabilization mechanisms and formulation development.
• Experience with standard analytical characterization techniques for biologics (SEC, IEC, CE-SDS, cIEF, RP-HPLC, particle characterization), assay troubleshooting and data interpretation.
• Demonstrated excellence in written and verbal communication, time management and working as part of a team.
• Good computer skills and working knowledge of Microsoft Office.
• Experience with biologics drug product process (e.g. filtration, lyophilization) and working in a GLP or GMP environment are a plus.