Director, In Vivo Pharmacology

Greater San Jose Area
Mar 27, 2018
Required Education
Position Type
Part time

Position Title:  Director, In Vivo Pharmacology

 Aridis Pharmaceuticals, Inc., located in San Jose California is seeking a Director of In Vivo Pharmacology to join our Preclinical team. This is a part-time position with the opportunity to convert to full-time. The successful candidate will lead in vivo efficacy and PK/PD studies to support antibody and small molecule drug development for infectious diseases. He or She will drive a critical component of the drug discovery and development process by ensuring the delivery of high quality in vivo data that enables Aridis’ antibody and small molecule programs to progress to clinical development.

Organizational relationships and resources managed:
The candidate will report to the CEO and collaborate extensively with Biology and Development teams. He or She will lead the internal pharmacology team and oversee outsourced activities.

Primary Responsibilities:

  • Lead design and execution of in vivo studies to establish the efficacy and PK/PD relationships for novel infectious disease therapeutics using a variety of rodent models, with particular emphasis on pneumonia models.
  • Identify and develop collaborations with CROs and academic institutions to employ novel in vivo models or utilize expertise not available in-house. Work closely with, monitor and report collaborator based studies to Aridis development project teams.
  • Manage and supervise study planning, protocol design, scheduling, internal resource allocation, study implementation and result publishing.
  • Oversee training of RAs on rodent care, dosing (IH, IV, IN, IT, SC), blood and tissue sampling, and surgeries as needed.
  • Oversee all vivarium operations
  • Manage projects with external clients and vendors


  • PhD or DVM in a relevant biological scientific discipline with a focus on respiratory diseases and at least 8 years of pharmaceutical industry experience.
  • Proven ability to lead an in vivo pharmacology team.
  • Strong understanding of key components and process of drug discovery, applied pharmacology and drug development.
  • Strong working knowledge of infectious disease processes, disease models, and current clinical treatments.
  • Thorough knowledge of the regulatory requirements to run an in vivo facility and to remain compliant with IACUC, DEA and AALAC regulations.
  • Experience with inhalation models preferred.
  • Experience and working knowledge in concepts including but not limited to histology/immunohistochemistry, FACS, in vivo imaging, etc. preferred
  • Strong communication skills and ability to work effectively in a multidisciplinary team environment.