Senior Scientist II
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.
More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.
General Position Summary/Purpose:
Provide strong scientific and technical leadership and hands-on implementation of compound screening assays for small-molecule drug development and new target identification/validation in the fields of hematologic malignancies and immuno-oncology. Conceive and execute novel scientific approaches to achieve departmental project goals.
Key Accountabilities/Core Job Responsibilities:
- Demonstrate scientific independence to establish and implement strategies for understanding the mechanisms of action of drugs and translation into future therapies for new indications in hematological malignancies and immune oncology.
- Design hypothesis-driven proposals and studies to inform structure-activity relationships or mechanisms of action of drugs in hematologic cancer such as CLL or non-Hodgkin lymphoma.
- Drive hypothesis-generating pre-clinical studies that inform mechanisms of resistance and/or rationales for therapeutic combinations.
- Hands-on execution : Advance science from the bench. Design and execute in vitro or ex vivo experiments to determine potency and selectivity of drug development compounds using cell lines and primary human cell sources. Lead the development, optimization, and validation of new assays.
- Apply cell and molecular biology techniques to identify and evaluate cellular efficacy and selectivity endpoints. Utilize technical expertise and available information to troubleshoot and resolve key project hurdles when encountered.
- Actively participate in internal and external scientific meetings by presenting and critically evaluating emerging scientific literature to contribute to projects.
- Perform and manage in-house, CRO, or collaborative research to support the development of therapies in a variety of hematological malignancies.
- Prioritize tasks and contribute to a highly motivated and productive research team with a sense of urgency and desire to meet project timelines.
- PhD with postdoctoral training plus a minimum of 3 years of industry experience in drug discovery, oncology, biochemistry, pharmacology, or related fields.
- Track record of contributing immunology/cancer drug discovery projects, significant expertise and extensive experience of drug development in the cancer immunology/autoimmune disease field.
- Strong track record of peer-reviewed publications and presentations at national meetings.
- Strong interpersonal skills to thrive in a team environment.
- Effective written and verbal communication skills.
- Expertise in multiple ELISA formats, western blotting, WES, cell culture, separation techniques for primary cells and cell-based assays is a must. Hands on experience with flow cytometry is strongly preferred. Experience with techniques to transduce cells with expression constructs such as transfections and viral infections is also preferred.
- Experience in establishing and fully validating compound potency assays using cell lines or primary human cells is essential.
- Experience in using cell biology models to elucidate molecular mechanisms of action.
- Broadly trained in immunology and cancer biology, as indicated by peer reviewed publication in top tier journals and presentations at national or international conferences.
- Working knowledge of lymphocyte biology, cell subsets, and lineage markers.
- Experience in managing direct report(s) in industrial settings is preferred but not essential.