Senior Scientist I/II, Cancer Genetics - Molecular Biology

Employer
AbbVie
Location
South San Francisco, California, USA
Posted
Mar 26, 2018
Ref
1801411
Required Education
Doctorate/PHD/MD
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at Stemcentrx, AbbVie's South San Francisco, CA location. POSITION DESCRIPTION: Senior Scientist I/II - Molecular Biology/Cancer Genetics
As part of a talented and multi-disciplinary team advancing exciting new approaches to drug discovery and development, AbbVie Stemcentrx is looking for a highly motivated scientist with direct experience in cancer genetics and molecular biology. AbbVie is a global, research-based biopharmaceutical company with a strong focus in oncology and its subsidiary Stemcentrx is a leader in identifying novel cancer stem cell targets and developing targeted antibody drug conjugate (ADC) therapies in oncology. The successful candidate will contribute to annotating and predicting the impact of genetic variants in tumors, and lead efforts to integrate gene mutation, gene expression, copy number variation, methylation, proteomics and other datasets across our large patient derived xenograft (PDX) bank of tumors, to aid in target and biomarker identification. Additionally, this scientist will lend expert molecular biology insights to confirm transcript isoform(s) expressed in tumor and normal tissues, ensure correct cloning of species homologs and consider single nucleotide polymorphisms (SNPs) that could alter antibody binding. Key Responsibilities Include:
  • Work with bench scientists and bioinformaticians to implement analytical pipeline of targeted mutation sequencing data to annotate and predict effect of genetic variants in tumors
  • Help develop analysis and visualization pipeline to combine gene mutation, gene expression, copy number variation, and methylation data to characterize and subtype tumors
  • Lend molecular biology expertise to nucleic acid isolation methods, NGS library construction, and RT-PCR and RACE to confirm transcript isoforms
  • Proactively seek out and incorporate cutting edge technologies
Qualifications:
  • Ph.D. in cancer genetics or molecular biology
  • Highly motivated, goal oriented and independent scientist with expertise in human cancer genetics and previous experience analyzing genetic variants and interpreting their functional impact in tumors
  • Familiarity with genomic data analysis tools and databases such as cBioPortal, COSMIC, ClinVar, SnpEff, UCSC Genome Browser
  • Technical expertise in molecular biology methods including cloning, nucleic acid isolation, qRT-PCR, next-generation sequencing (mutation analysis and gene expression), etc. as well as experience with corresponding data analysis methods
  • Excellent oral and written communication skills and a proven track record of working effectively with bioinformaticians and/or software developers

**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**