Research Associate II/III

Location
Berkeley, California
Posted
Mar 23, 2018
Ref
18-021N
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
 This position will be responsible for providing analytical chemistry and formulation support for small molecule, oligonucleotide and protein-based drug candidates to  advance Dynavax’s immuno-oncology research programs in the field of Toll Receptor agonism.

 

 

 

Responsibilities
  • ·         Conduct laboratory-based analytical chemistry and formulation research activities with small molecule, oligonucleotide and/or protein-based drug candidates, including; compound formulation, sample management, analytical method development / optimization, and bioconjugation chemistry.

     

    ·         Contribute to the design and execution of in vitro and in vivo PK/DM experiments.

     

    ·         Execute experimental protocols and collect / record results, must be able to effectively troubleshoot experiment procedures.

     

    ·         Analyze experimental data, prepare and submit technical reports, and present results at project team and departmental meetings.

     

    ·         Coordinate day-to-day laboratory activities to ensure reagents are available and maintenance of equipment.

     

    ·         Document all scientific work in lab notebooks, follow established Dynavax standard operating procedures on data documentation and notebooks, and adhere to Dynavax Quality Systems standards.

     

    ·         Support the organization in maintaining a work environment focused on quality and that fosters learning, open communication, collaboration, integration, and team work.

     

    ·         Other duties as assigned.

     


 

Qualifications
·         BS or MS in life science, either in chemistry, biochemistry and/or other related discipline.

 

·         Required experience will vary depending on level:  RA II level with BS and 3+ years relevant experience; RA III level with BS and 5+ years, or an MS with 2+ years’ of relevant experience.

 

·         Relevant laboratory experience includes:

-   small molecule / oligonucleotide / protein compound formulation and management.

-   purification / analysis of small molecules, oligonucleotides, and / or proteins by high or low pressure LC methods (RP, SEC, HIC, etc.).

-   other analytical methods, including SDS-PAGE, UV spectroscopy, DLS, zeta-potential, endotoxin determination, etc.

-   familiarity with bioconjugation chemistries / methodology.

-   experience with harvesting tissues from laboratory mice and processing for bioanalysis.

 

·         Proficiency with Word, Excel, Powerpoint, Prism, and ChemDraw software.

 

·         Must be capable of working independently, have careful attention to experimental details, and possess excellent record-keeping and strong organizational skills. 

 

·         Excellent written and verbal communication skills.

 

Additional knowledge and skills desired, but not required:

·         Mass spectroscopy and its application to the field of biotechnology.

 

·         Familiarity with fundamental concepts in immuno-oncology.