2018 Experiential Intern (Undergraduate) - Manufacturing Science & Technology

Employer
AbbVie
Location
Lake County, Illinois, USA
Posted
Mar 23, 2018
Ref
1707927
Required Education
Bachelors Degree
Position Type
Full time

The AbbVie Experiential Internship Program

As an AbbVie Experiential Intern, you'll participate in a paid, ten to twelve-week summer program that is focused on providing students with robust projects throughout the summer. As an intern, you will be located at our corporate headquarters in north suburban Chicago, with housing and shuttle services for eligible students.

Department Overview - Manufacturing Science & Technology: Drug Product Group

The Drug Products department in operations supports the scale-up and commercial manufacture of solid oral dosage forms, such as tablets and capsules. Scientists and engineers in this department are exposed to numerous manufacturing techniques, and work with both R&D and our manufacturing plants to improve our processes.

Assignment Details

Background:

The idea is to use spectroscopy (visual and NIR, potentially UV) to analyze the product from the hot melt extrusion on-line, and link the analysis of a product to process parameters. This can be used to develop PAT to analyze product attributes online, and has broad application to HME products.

Goals:

  • Compare in-line spectroscopic tools (optical, NIR, and UV) in characterizing the impact of hot melt extrusion process parameters to extrudate properties.
  • Develop a toolbox of techniques and models that can be used to characterize residence time distribution and optical clarity for a variety of AbbVie formulations and processes.

Proposed approach:

  • Utilizing standard copovidone-based placebo formulations, evaluate the in-line spectroscopic response to changes in fundamental extrusion parameters, such as screw design, scalable throughput and barrel temperatures.
  • Utilizing multivariate techniques, correlate the in-line spectroscopic responses to product characteristics (optical clarity due to air bubbles or surfactant level) and process characteristics (residence time distribution).
  • Utilizing a model compound blended into copovidone to assess use of NIR to detect extrudate composition

Qualifications:

Basic:

  • Completed at least one year of college education before beginning internship
  • Must be enrolled in school the semester following your internship
  • BA/BS Undergraduate Student
  • Minimum Cumulative GPA: 3.0/4.0
  • Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship (students on an F1 visa with CPT can be accommodated)
  • Majoring in chemical engineering, materials science engineering, mechanical engineering

Equal Opportunity Employer Minorities/Women/Veterans/Disabled