Associate Director, Antibody Engineering

Employer
Tri-I TDI
Location
Manhattan, Upper East side
Posted
Mar 22, 2018
Required Education
Doctorate/PHD/MD
Position Type
Full time

The Tri-Institutional Therapeutics Discovery Institute (Tri-I TDI) seeks a highly motivated and enthusiastic individual to lead efforts in the design and engineering of antibodies and antibody-based therapeutics. The Tri-I TDI, a partnership of Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medicine, links researchers in basic and clinical science with experts in drug discovery from the biotech and pharmaceutical industries, with the goal of more efficiently translating discoveries into therapies for disease. The engineering effort will support exploratory and advanced projects across the biologics discovery portfolio through format design and optimization of biologic drug properties. The Associate Director will also have project management responsibilities; work closely with industrial partners and academic collaborators, and present progress reports to the project teams.

Position Activities:

  • Establishes a laboratory for antibody engineering to support the biologics discovery portfolio.
  • Identifies, defines and implements processes for design and optimization of antibody-based scaffolds including bi-specifics and ADCs, and optimization of drug properties of lead molecules to support progression of projects across the portfolio.
  • Oversees the daily operations of the antibody engineering team, including sequence and structure-based analysis and modeling, sequence optimization, affinity maturation, humanization, sequence de-immunization and antibody stabilization.
  • Collaborates with the principal investigators at the academic institutions to identify and generate therapeutically relevant formats and optimize drug properties.
  • Recruits and manages technical support staff.
  • Provides technical training as needed in all aspects of antibody engineering.
  • Manages projects from the biologics discovery portfolio in close collaboration with the industry partner and the principal investigators at the academic institutions.
  • Submits progress reports and presents project updates at meetings with the principal investigators and the Tri-I TDI leadership team.
  • Keeps current with literature and emerging trends in the discipline.

Minimum Requirements

  • PhD degree in biochemistry, molecular biology, structural biology, or related field.
  • A minimum of 5 years of experience working in antibody engineering, preferably in the pharmaceutical or biotechnology industry.
  • Experience in biologics drug discovery and pre-clinical development.
  • Demonstrated track record with publications or patents.
  • Expertise in project planning and management.

Skill and Abilities

  • In-depth knowledge of state-of-the-art technologies and methods for design and optimization of antibody and antibody-based therapeutics.
  • Proficiency in antibody and protein modeling using Rosetta, Schrodinger or similar tools.
  • Critical independent thinking, prioritization of tasks, strong problem-solving and excellent communication skills.
  • Timely delivery of team goals and ability to build productive relationships with colleagues, collaboration partners, and stakeholders.